Molecular structure of 4′-Hydroxy Atomoxetine-d3
4′-Hydroxy Atomoxetine-d3 (CAS 1217686-14-0)
Alternate Names:
4-Hydroxyatomoxetine-d3; 3-Methyl-4-(3-methylamino-d3-1-phenyl-propoxy)-phenol
Application:
4′-Hydroxy Atomoxetine-d3 is a labeled metabolite of Tomoxetine
CAS Number:
1217686-14-0
Molecular Weight:
274.37
Molecular Formula:
C17H18D3NO2
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4′-Hydroxy Atomoxetine-d3 is a labeled metabolite of Tomoxetine. Tomoxetine (Atomoxetine, LY 139603; sc-204349) is a competitve and specific inhibitor of norepinephrine reuptake while demonstrating weak serotonin and dopamine inhibition as studied in synaptosomes of rat hypothalamus. Additional studies indicate that this (−) optical isomer is more effective than the (+) isomer, LY139602 (ent S-(+)-Atomoxetine Hydrochloride; sc-211408). Additionally, in the prefrontal cortex of rats, Tomoxetine was reported to not cause an increase in dopamine within the striatum or nucleus accumbens which may be useful in additional research studies investigating the reward pathways of the brain.
4′-Hydroxy Atomoxetine-d3 (CAS 1217686-14-0) References
- Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. | Bymaster, FP., et al. 2002. Neuropsychopharmacology. 27: 699-711. PMID: 12431845
- Catecholamine influences on dorsolateral prefrontal cortical networks. | Arnsten, AF. 2011. Biol Psychiatry. 69: e89-99. PMID: 21489408
- A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. | Wong, DT., et al. 1982. J Pharmacol Exp Ther. 222: 61-5. PMID: 6123593
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4′-Hydroxy Atomoxetine-d3, 1 mg | sc-217052 | 1 mg | $550.00 |