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4-Pregnen-17α,20β-diol-3-one (CAS 1662-06-2)

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Alternate Names:
17α, 20β-DIHYDROXYPROGESTERONE
Application:
4-Pregnen-17α,20β-diol-3-one is a C-21 steroid hormone that supports embryogenesis
CAS Number:
1662-06-2
Molecular Weight:
332.48
Molecular Formula:
C21H32O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Pregnen-17α,20β-diol-3-one is a C-21 steroid hormone that supports embryogenesis in various species. It is a metabolite of progesterone found in blood and acts as a precursor to other hormones, such as cortisol and aldosterone. It has been demonstrated to aid in the development of the fetus by raising EGF-1 levels, regulating the immune response and numerous other effects.


4-Pregnen-17α,20β-diol-3-one (CAS 1662-06-2) References

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  2. Enzymatic characteristics and subcellular distribution of a short-chain dehydrogenase/reductase family protein, P26h, in hamster testis and epididymis.  |  Ishikura, S., et al. 2001. Biochemistry. 40: 214-24. PMID: 11141073
  3. Adrenal and sex steroid receptor evolution: environmental implications.  |  Baker, ME. 2001. J Mol Endocrinol. 26: 119-25. PMID: 11241163
  4. Cloning of transforming growth factor-beta 1 (TGF-beta 1) and its type II receptor from zebrafish ovary and role of TGF-beta 1 in oocyte maturation.  |  Kohli, G., et al. 2003. Endocrinology. 144: 1931-41. PMID: 12697700
  5. Short-term exposure to 17 alpha-ethynylestradiol decreases the fertility of sexually maturing male rainbow trout (Oncorhynchus mykiss).  |  Schultz, IR., et al. 2003. Environ Toxicol Chem. 22: 1272-80. PMID: 12785584
  6. Changes in the activities of hydroxysteroid dehydrogenases in mouse oocytes during meiotic maturation.  |  Niimura, S. and Kawakami, SY. 2003. J Reprod Dev. 49: 451-6. PMID: 14967895
  7. Inactivation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase enzymes increases during the meiotic maturation of porcine oocytes.  |  Webb, RJ., et al. 2008. Reproduction. 136: 725-32. PMID: 18787080
  8. Ovarian development and related changes in steroid hormones in female wild common carp (Cyprinus carpio carpio), from the south-eastern Caspian Sea.  |  Vazirzadeh, A., et al. 2014. J Anim Physiol Anim Nutr (Berl). 98: 1060-7. PMID: 24621281
  9. Nuclear progestin receptor (pgr) knockouts in zebrafish demonstrate role for pgr in ovulation but not in rapid non-genomic steroid mediated meiosis resumption.  |  Zhu, Y., et al. 2015. Front Endocrinol (Lausanne). 6: 37. PMID: 25852646
  10. A Neural Basis for Control of Cichlid Female Reproductive Behavior by Prostaglandin F2α.  |  Juntti, SA., et al. 2016. Curr Biol. 26: 943-9. PMID: 26996507
  11. Phoenixin-20 Stimulates mRNAs Encoding Hypothalamo-Pituitary-Gonadal Hormones, is Pro-Vitellogenic, and Promotes Oocyte Maturation in Zebrafish.  |  Rajeswari, JJ. and Unniappan, S. 2020. Sci Rep. 10: 6264. PMID: 32286445
  12. Characterization of an androgen receptor in salmonid lymphocytes: possible link to androgen-induced immunosuppression.  |  Slater, CH., et al. 1995. Gen Comp Endocrinol. 100: 218-25. PMID: 8582603
  13. The steroid pheromone 4-pregnen-17,20ss-diol-3-one increases fertility and paternity in goldfish.  |  Zheng, W., et al. 1997. J Exp Biol. 200: 2833-40. PMID: 9344969
  14. 20beta-hydroxy-C21-steroid 20beta-oxidase activity of cytochrome P450c21 purified from bovine adrenocortical microsomes.  |  Tsubaki, M., et al. 1998. Biochim Biophys Acta. 1390: 197-206. PMID: 9507127

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Pregnen-17α,20β-diol-3-one, 10 mg

sc-210147
10 mg
$237.00