Date published: 2026-4-4

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4-Piperidone Monohydrate Hydrochloride (CAS 40064-34-4)

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CAS Number:
40064-34-4
Molecular Weight:
153.61
Molecular Formula:
C5H9NO•H2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Piperidone Monohydrate Hydrochloride a favorable reagent in various chemical reactions. It is valued for its versatility in the synthesis of chemical entities, including agrochemicals and novel organic compounds. Its utility lies in the lactam ring, which serves as a scaffold for the introduction of various functional groups, enabling the construction of complex molecular architectures through subsequent chemical modifications. 4-Piperidone Monohydrate Hydrochloride is used to explore new synthetic routes and methodologies, contributing to the advancement of synthetic organic chemistry. Its role extends to the study of cyclization reactions, where it acts as a precursor for the synthesis of heterocyclic compounds. It is also noted in its application as a starting material or intermediate in the synthesis of alkaloids and other nitrogen-containing compounds. Its structural flexibility and reactivity make it useful for chemists aiming to design and synthesize molecules with specific properties or biological activities.


4-Piperidone Monohydrate Hydrochloride (CAS 40064-34-4) References

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  2. Design, cytotoxic and fluorescent properties of novel N-phosphorylalkyl substituted E,E-3,5-bis(arylidene)piperid-4-ones.  |  Makarov, MV., et al. 2009. Eur J Med Chem. 44: 2135-44. PMID: 19046794
  3. Use of 4-piperidones in one-pot syntheses of novel, high-molecular-weight linear and virtually 100%-hyperbranched polymers.  |  Cruz, AR., et al. 2009. Chem Commun (Camb). 4408-10. PMID: 19597608
  4. CLEFMA-an anti-proliferative curcuminoid from structure-activity relationship studies on 3,5-bis(benzylidene)-4-piperidones.  |  Lagisetty, P., et al. 2010. Bioorg Med Chem. 18: 6109-20. PMID: 20638855
  5. Anticancer activity of an imageable curcuminoid 1-[2-aminoethyl-(6-hydrazinopyridine-3-carbamidyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone (EFAH).  |  Lagisetty, P., et al. 2012. Chem Biol Drug Des. 79: 194-201. PMID: 22107757
  6. Ultrasound-promoted synthesis of novel bipodal and tripodalpiperidin-4-ones and silica chloride mediated conversion to its piperidin-4-ols: synthesis and structural confinements.  |  Rajesh, K., et al. 2012. Ultrason Sonochem. 19: 522-31. PMID: 22129974
  7. Design, synthesis and bioevaluation of novel N-substituted-3,5-bis(arylidene)-4-piperidone derivatives as cytotoxic and antitumor agents with fluorescent properties.  |  Sun, J., et al. 2014. Chem Biol Drug Des. 83: 392-400. PMID: 24148151
  8. Antibacterial activity of synthetic curcumin derivatives: 3,5-bis(benzylidene)-4-piperidone (EF24) and EF24-dimer linked via diethylenetriaminepentacetic acid (EF2DTPA).  |  Vilekar, P., et al. 2014. Appl Biochem Biotechnol. 172: 3363-73. PMID: 24532443
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  10. Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts.  |  Roayapalley, PK., et al. 2021. Molecules. 26: PMID: 34885719
  11. Two novel piperidones induce apoptosis and antiproliferative effects on human prostate and lymphoma cancer cell lines.  |  Swain, RM., et al. 2022. Invest New Drugs. 40: 905-921. PMID: 35793039
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Piperidone Monohydrate Hydrochloride, 25 g

sc-210144
25 g
$117.00

4-Piperidone Monohydrate Hydrochloride, 1 kg

sc-210144A
1 kg
$1224.00