Molecular structure of 4-Phenylbutyric acid, CAS Number: 1821-12-1
4-Phenylbutyric acid (CAS 1821-12-1)
See product citations (10)
Alternate Names:
4-phenylbutanoic acid
Application:
4-Phenylbutyric acid is a chemical chaperone that suppresses oxidative stress
CAS Number:
1821-12-1
Molecular Weight:
164.20
Molecular Formula:
C10H12O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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4-Phenylbutyric acid is a chemical chaperone, which suppresses oxidative stress by attenuating endoplasmic reticulum stress. 4-Phenylbutyric acid increases the expression of type 2 deiodinase (D2), via the accumulation of Dio2 mRNA. Studies indicate that 4-Phenylbutyric acid affects genes such as Ucp-1, Ucp-3 and Pgc-1alpha in a D2-dependent manner. The activation of these genes is thought to increase T3 production. Diabetic studies conducted on mice suggest that 4-Phenylbutyric acid normalizes serum glucose levels.
4-Phenylbutyric acid (CAS 1821-12-1) References
- 4-Phenyl butyric acid does not generally reduce glucose levels in rodent models of diabetes. | Xu, TY., et al. 2010. Clin Exp Pharmacol Physiol. 37: 441-6. PMID: 19878212
- Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: regulation of endoplasmic reticulum stress-oxidative activation. | Luo, ZF., et al. 2010. Toxicol Appl Pharmacol. 246: 49-57. PMID: 20399799
- The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. | da-Silva, WS., et al. 2011. FEBS Lett. 585: 539-44. PMID: 21237159
- 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. | Park, HJ., et al. 2018. Biochem Pharmacol. 151: 9-17. PMID: 29458048
- 4-phenylbutyric acid attenuates endoplasmic reticulum stress-mediated apoptosis and protects the hepatocytes from intermittent hypoxia-induced injury. | Xin, L., et al. 2019. Sleep Breath. 23: 711-717. PMID: 30324548
- 4-Phenylbutyric acid enhances the mineralization of osteogenesis imperfecta iPSC-derived osteoblasts. | Takeyari, S., et al. 2021. J Biol Chem. 296: 100027. PMID: 33154166
- 4-Phenylbutyric acid protects islet β cell against cellular damage induced by glucocorticoids. | Zhou, X., et al. 2021. Mol Biol Rep. 48: 1659-1665. PMID: 33566227
- 4-phenylbutyric acid mediates therapeutic effect in systemic lupus erythematosus: Observations in an experimental murine lupus model. | Choi, Y., et al. 2021. Exp Ther Med. 21: 460. PMID: 33747192
- 4-Phenylbutyric acid, a potent endoplasmic reticulum stress inhibitor, attenuates the severity of collagen-induced arthritis in mice via inhibition of proliferation and inflammatory responses of synovial fibroblasts. | Choi, Y., et al. 2021. Kaohsiung J Med Sci. 37: 604-615. PMID: 33759334
- 4-phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR-α. | Chen, SZ., et al. 2021. Clin Transl Med. 11: e379. PMID: 33931972
- Neuroprotective Effect of 4-Phenylbutyric Acid against Photo-Stress in the Retina. | Guzmán Mendoza, NA., et al. 2021. Antioxidants (Basel). 10: PMID: 34356380
- 4-Phenylbutyric acid accelerates rehabilitation of barrier function in IPEC-J2 cell monolayer model. | Jiang, Q., et al. 2021. Anim Nutr. 7: 1061-1069. PMID: 34738036
- 4-Phenylbutyric acid alleviates 3-acetyldeoxynivalenol-induced immune cells response by inhibiting endoplasmic reticulum stress in mouse spleen. | Jia, H., et al. 2022. Food Chem Toxicol. 164: 113002. PMID: 35413383
- 4-phenylbutyric acid-Identity crisis; can it act as a translation inhibitor? | Stein, D., et al. 2022. Aging Cell. 21: e13738. PMID: 36373957
- Andrographolide and 4-Phenylbutyric Acid Administration Increase the Expression of Antimicrobial Peptides Beta-Defensin-1 and Cathelicidin and Reduce Mortality in Murine Sepsis. | Bolatchiev, A., et al. 2022. Antibiotics (Basel). 11: PMID: 36421273
Inhibitor of:
β-2-Microglobulin, 9030025P20Rik, C19orf69, cathepsin G, CLEC-2F, CLEC-2G, CREB3L2, CYP4B1, Derlin-2, ERdj4, GADD 153, HSPC171, HUGT2, Lipocalin-10, Membralin, PDC-E2, PDIR, PERK, PPP1R15B, Sec31, TMCO4, and Torsin3A.Activator of:
ALR, Apg-2 (HSPA4), Arylsulfatase, ASGPR2, ATF-6α, Calnexin, CALR4, caspase-12, CSP, DnaJC3, EDEM3, ELOVL1, ELOVL5, ERGIC-53, Ero1-Lα, ERp27, ERp29, ERp46, FDXACB1, FKBP10, GALE, Glucosidase IIα, Gm10332, Gm11062, Gm13247, Gm14139, Gm14306, Gm15070, HDEL, hnRNP A2/B1, IRE1β, ITM1, KDEL ER Marker, KDEL receptor, MAN1A2, MAN2A2, n-Octylthioglucoside, NPIPL3, Nup62-il4i1, OBP-B, Olfr1053, Olfr1354, Olfr157, Olfr209, Olfr251, Olfr305, PDI, PDI1 ER and Nuclear Envelope Marker, PDIA2, PDILT, PHLDA3, prefoldin 4, REEP6, Rer1, reticulocalbin-2, RRBP1, SDSL, SEC23B, Sec62, Sec63, SLC35B2, SPC12, TMEM39A, TMEM92, TMUB2, TSR3, TXNDC1, TXNDC15, VSV-G, Wolframin, and XylT-I.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Phenylbutyric acid, 25 g | sc-232961 | 25 g | $53.00 | |||
4-Phenylbutyric acid, 100 g | sc-232961A | 100 g | $136.00 | |||
4-Phenylbutyric acid, 500 g | sc-232961B | 500 g | $418.00 |