Molecular structure of 4-Phenylbutyl isothiocyanate, CAS Number: 61499-10-3
4-Phenylbutyl isothiocyanate (CAS 61499-10-3)
Application:
4-Phenylbutyl isothiocyanate is an inducer of Phase II detoxifying enzymes
CAS Number:
61499-10-3
Molecular Weight:
191.29
Molecular Formula:
C11H13NS
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
4-Phenylbutyl isothiocyanate is a synthetic phenyl alkyl isothiocyanate that has displayed induction of Phase II detoxifying enzymes. Also inhibits chemically induced carcinogenesis. 4-Phenylbutyl isothiocyanate is an activator of JNK1.
4-Phenylbutyl isothiocyanate (CAS 61499-10-3) References
- Modifying effects of 4-phenylbutyl isothiocyanate on N-nitrosobis(2-oxopropyl)amine-induced tumorigenesis in hamsters. | Son, HY., et al. 2000. Cancer Lett. 160: 141-7. PMID: 11053643
- Simultaneous treatment with benzyl isothiocyanate, a strong bladder promoter, inhibits rat urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine. | Okazaki, K., et al. 2002. Nutr Cancer. 42: 211-6. PMID: 12416262
- Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl)nitrosamine in rats after initiation. | Okazaki, K., et al. 2003. Cancer Sci. 94: 948-52. PMID: 14611670
- Suppression of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters by pioglitazone, a ligand of peroxisome proliferator-activated receptor gamma. | Takeuchi, Y., et al. 2007. Carcinogenesis. 28: 1692-6. PMID: 17449904
- Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. | Morse, MA., et al. 1991. Cancer Res. 51: 1846-50. PMID: 2004368
- A/J mouse lung tumorigenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by arylalkyl isothiocyanates. | Hecht, SS., et al. 1991. Exp Lung Res. 17: 501-11. PMID: 2050046
- Volatile constituents and antioxidant activity of flowers, stems and leaves of Nasturtium officinale R. Br. | Amiri, H. 2012. Nat Prod Res. 26: 109-15. PMID: 21815727
- Distribution and metabolism of the natural anticarcinogen phenethyl isothiocyanate in A/J mice. | Eklind, KI., et al. 1990. Carcinogenesis. 11: 2033-6. PMID: 2225337
- Glucosinolate-Derived Isothiocyanates Inhibit Arabidopsis Growth and the Potency Depends on Their Side Chain Structure. | Urbancsok, J., et al. 2017. Int J Mol Sci. 18: PMID: 29117115
- Effect of alkyl chain length on inhibition of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis and DNA methylation by isothiocyanates. | Wilkinson, JT., et al. 1995. Carcinogenesis. 16: 1011-5. PMID: 7767958
- Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone mouse lung tumorigenesis by arylalkynes, mechanism-based inactivators of cytochrome P450. | Alworth, WL., et al. 1993. Carcinogenesis. 14: 1711-3. PMID: 8353857
- Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. | Guo, Z., et al. 1993. Carcinogenesis. 14: 1167-73. PMID: 8508504
- Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1. | Yu, R., et al. 1996. Cancer Res. 56: 2954-9. PMID: 8674048
Activator of:
JNK1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Phenylbutyl isothiocyanate, 1 g | sc-205582 | 1 g | $68.00 | |||
4-Phenylbutyl isothiocyanate, 5 g | sc-205582A | 5 g | $349.00 |