Date published: 2025-11-3

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4-Pentyne-1-thiol (CAS 77213-88-8)

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CAS Number:
77213-88-8
Molecular Weight:
100.18
Molecular Formula:
C5H8S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-pentyne-1-thiol or PT, is an organic compound classified as a thiol. This colorless liquid possesses a distinct odor. Its applications are primarily found in scientific research. One of the key functions of 4-Pentyne-1-thiol is its interaction with thiol groups present in proteins, resulting in the formation of disulfide bonds. These bonds are for maintaining protein stability and functionality. Moreover, 4-Pentyne-1-thiol can act as a reducing agent to break disulfide bonds, which is significant in the examination of protein redox states.


4-Pentyne-1-thiol (CAS 77213-88-8) References

  1. Generation and cyclization of unsaturated carbamoyl radicals derived from S-4-pentynyl carbamothioates under tin-free conditions.  |  Benati, L., et al. 2006. J Org Chem. 71: 3192-7. PMID: 16599618
  2. Tin-free generation of alkyl radicals from alkyl 4-pentynyl sulfides via homolytic substitution at the sulfur atom.  |  Bencivenni, G., et al. 2008. Org Lett. 10: 1127-30. PMID: 18278931
  3. Radical Chain Reaction of Benzenethiol with Pentynylthiol Esters: Production of Aldehydes under Stannane/Silane-Free Conditions  |  Luisa Benati*, Rino Leardini, Matteo Minozzi, Daniele Nanni, Rosanna Scialpi, Piero Spagnolo*, Giuseppe Zanardi. 2004. Synlett. 6: 987-990.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Pentyne-1-thiol, 250 mg

sc-478855
250 mg
$380.00