Molecular structure of 4-Oxo-4-(3-pyridyl)-butanal, CAS Number: 76014-80-7
4-Oxo-4-(3-pyridyl)-butanal (CAS 76014-80-7)
Alternate Names:
γ-Oxo-3-pyridinebutanal; 4-Oxo-1-(3-pyridyl)-1-butanone
Application:
4-Oxo-4-(3-pyridyl)-butanal is a NNK metabolite where NNK is a tobacco-specific nitrosamine
CAS Number:
76014-80-7
Molecular Weight:
163.18
Molecular Formula:
C9H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
An NNK metabolite where NNK is a tobacco-specific nitrosamine.
4-Oxo-4-(3-pyridyl)-butanal (CAS 76014-80-7) References
- Lack of correlation between DNA methylation and hepatocarcinogenesis in rats and hamsters treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | Liu, L., et al. 1992. Carcinogenesis. 13: 2137-40. PMID: 1423885
- Modulation by glutathione of DNA strand breaks induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its aldehyde metabolites in rat hepatocytes. | Demkowicz-Dobrzanski, K. and Castonguay, A. 1992. Carcinogenesis. 13: 1447-54. PMID: 1499096
- Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. | Hecht, SS., et al. 2007. Chem Res Toxicol. 20: 543-9. PMID: 17291014
- Comparison of DNA alkali-labile sites induced by 4-(methylnitrosamino)-1(3-pyridyl)-1-butanone and 4-oxo-4-(3-pyridyl)butanal in rat hepatocytes. | Demkowicz-Dobrzanski, K. and Castonguay, A. 1991. Carcinogenesis. 12: 2135-40. PMID: 1934300
- A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice. | Hollander, MC., et al. 2011. Carcinogenesis. 32: 1279-84. PMID: 21625009
- Cytotoxicity, sister-chromatid exchanges and DNA single-strand breaks induced by 4-oxo-4-(3-pyridyl)butanal, a metabolite of a tobacco-specific N-nitrosamine. | Alaoui-Jamali, MA., et al. 1990. Mutat Res. 240: 25-33. PMID: 2294414
- Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model. | Megaraj, V., et al. 2014. Carcinogenesis. 35: 131-7. PMID: 23917075
- Metabolites of Tobacco- and E-Cigarette-Related Nitrosamines Can Drive Cu2+-Mediated DNA Oxidation. | Kankanamage, RNT., et al. 2020. Chem Res Toxicol. 33: 2072-2086. PMID: 32672941
- Identification of Formaldehyde-Induced DNA-RNA Cross-Links in the A/J Mouse Lung Tumorigenesis Model. | Dator, RP., et al. 2022. Chem Res Toxicol. 35: 2025-2036. PMID: 36356054
- Simultaneous solid-phase extraction and gas chromatographic-mass spectrometric determination of hemoglobin adducts from tobacco-specific nitrosamines and aromatic amines. | Kutzer, C., et al. 1997. J Chromatogr Sci. 35: 1-6. PMID: 8989869
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Oxo-4-(3-pyridyl)-butanal, 25 mg | sc-210139 | 25 mg | $2327.00 | |||
4-Oxo-4-(3-pyridyl)-butanal, 50 mg | sc-210139A | 50 mg | $4500.00 | |||
4-Oxo-4-(3-pyridyl)-butanal, 100 mg | sc-210139B | 100 mg | $8000.00 | |||
4-Oxo-4-(3-pyridyl)-butanal, 1 g | sc-210139C | 1 g | $24000.00 | |||
4-Oxo-4-(3-pyridyl)-butanal, 5 g | sc-210139D | 5 g | $39500.00 |