Date published: 2026-4-28

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4-Nonylphenol (CAS 104-40-5)

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Alternate Names:
4-n-Nonylphenol
CAS Number:
104-40-5
Molecular Weight:
220.35
Molecular Formula:
C15H24O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Nonylphenol (4-NP) is an organic compound widely utilized across industrial and commercial sectors owing to its affordability and abundant availability. Functioning as a nonionic surfactant, it is a commonplace ingredient in detergents, cleaners, and personal care products. Although the precise mechanism of action remains incompletely understood, it is recognized that 4-nonylphenol interacts with various hormones and receptors. Furthermore, 4-Nonylphenol has been observed to interact with nuclear receptors, proteins that selectively bind to molecules and regulate gene expression.


4-Nonylphenol (CAS 104-40-5) References

  1. 4-Nonylphenol reduces cell viability and induces apoptosis and ER-stress in a human epithelial intestinal cell line.  |  Lepretti, M., et al. 2015. Toxicol In Vitro. 29: 1436-44. PMID: 25998160
  2. The Impact of 4-Nonylphenol on the Viability and Hormone Production of Mouse Leydig Cells.  |  Jambor, T., et al. 2016. Folia Biol (Praha). 62: 34-9. PMID: 27085008
  3. Adverse stimulation of 4-nonylphenol in abnormal reproductive organs of female chickens.  |  Zhang, F., et al. 2017. Oncotarget. 8: 110029-110038. PMID: 29299127
  4. Immunotoxic effects of 4-nonylphenol on Clarias gariepinus: Cytopathological changes in hepatic melanomacrophages.  |  Sayed, AEH., et al. 2019. Aquat Toxicol. 207: 83-90. PMID: 30537592
  5. Degradation of 4-nonylphenol in marine sediments by persulfate over magnetically modified biochars.  |  Dong, CD., et al. 2019. Bioresour Technol. 281: 143-148. PMID: 30818265
  6. 4-Nonylphenol-enhanced EZH2 and RNF2 expression, H3K27me3 and H2AK119ub1 marks resulting in silencing of p21CDKN1A in vitro.  |  Ghosh, K., et al. 2019. Epigenomics. 11: 899-916. PMID: 31144530
  7. Removal and biotransformation of 4-nonylphenol by Arthrospira maxima and Chlorella vulgaris consortium.  |  López-Pacheco, IY., et al. 2019. Environ Res. 179: 108848. PMID: 31678727
  8. Rapid analysis of 4-nonylphenol by solid phase microextraction in water samples.  |  Vargas-Berrones, K., et al. 2020. Talanta. 209: 120546. PMID: 31891999
  9. 4-Nonylphenol and 4-tert-octylphenol induce anxiety-related behaviors through alternation of 5-HT receptors and transporters in the prefrontal cortex.  |  Yang, J., et al. 2020. Comp Biochem Physiol C Toxicol Pharmacol. 230: 108701. PMID: 31911191
  10. 4-Nonylphenol degradation changes microbial community of scale-up Anaerobic Fluidized Bed Reactor.  |  Dornelles, HS., et al. 2020. J Environ Manage. 267: 110575. PMID: 32349961
  11. Protective Effect of Sodium Selenite on 4-Nonylphenol-Induced Hepatotoxicity and Nephrotoxicity in Rats.  |  Boyacioglu, M., et al. 2021. Biol Trace Elem Res. 199: 3001-3012. PMID: 33026593
  12. Degradation of the endocrine-disrupting 4-nonylphenol by ferrate(VI): biodegradability and toxicity evaluation.  |  Limmun, W., et al. 2022. Environ Sci Pollut Res Int. 29: 18882-18890. PMID: 34705206
  13. Biomonitoring of bisphenol A, 4-nonylphenol, and 4-t-octylphenol in Turkish population: exposure and risk assessment.  |  Sukuroglu, AA., et al. 2022. Environ Sci Pollut Res Int. 29: 26250-26262. PMID: 34850348
  14. Degradation of 4-nonylphenol in marine sediments using calcium peroxide activated by water hyacinth (Eichhornia crassipes)-derived biochar.  |  Hung, CM., et al. 2022. Environ Res. 211: 113076. PMID: 35271836
  15. Removal of 4-nonylphenol in activated sludge by peroxymonosulfate activated with sorghum distillery residue-derived biochar.  |  Hung, CM., et al. 2022. Bioresour Technol. 360: 127564. PMID: 35788388

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Nonylphenol, 100 mg

sc-256816
100 mg
$67.00

4-Nonylphenol, 5 g

sc-256816A
5 g
$401.00