Molecular structure of 4-Nitrophenyl N-acetyl-α-D-galactosaminide, CAS Number: 23646-68-6
4-Nitrophenyl N-acetyl-α-D-galactosaminide (CAS 23646-68-6)
Alternate Names:
p-Nitrophenyl 2-acetamido-2-deoxy-α-D-galactopyranoside; pNP-GlcNAc
Application:
4-Nitrophenyl N-acetyl-α-D-galactosaminide is a chromogenic substrate for N-acetyl-D-galactosaminidase, generating a yellow solution upon cleavage
CAS Number:
23646-68-6
Purity:
≥98%
Molecular Weight:
342.30
Molecular Formula:
C14H18N2O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Nitrophenyl N-acetyl-alpha-D-galactosaminide is a chromogenic substrate for N-acetyl-D-galactosaminidase, generating a yellow solution upon N-acetyl-D-galactosaminidase catalyzed cleavage of N-acetylglucosamine (GlcNAc). It may act to inhibit the binding of certain carbohydrates to lectins and the activity of certain glycosyltransferases. This compound has been used in a variety of scientific research applications, including enzyme kinetics, protein-carbohydrate interactions, and structural studies.
4-Nitrophenyl N-acetyl-α-D-galactosaminide (CAS 23646-68-6) References
- Lectin-sugar interaction. Calculated versus experimental binding energies. | Neumann, D., et al. 2002. Eur J Biochem. 269: 1518-24. PMID: 11874467
- Identification, molecular cloning and expression of an alpha-N-acetylgalactosaminidase gene from Clostridium perfringens. | Calcutt, MJ., et al. 2002. FEMS Microbiol Lett. 214: 77-80. PMID: 12204375
- Detachment of Actinobacillus actinomycetemcomitans biofilm cells by an endogenous beta-hexosaminidase activity. | Kaplan, JB., et al. 2003. J Bacteriol. 185: 4693-8. PMID: 12896987
- Novel endo-alpha-N-acetylgalactosaminidases with broader substrate specificity. | Koutsioulis, D., et al. 2008. Glycobiology. 18: 799-805. PMID: 18635885
- Loss of a biofilm-inhibiting glycosyl hydrolase during the emergence of Yersinia pestis. | Erickson, DL., et al. 2008. J Bacteriol. 190: 8163-70. PMID: 18931111
- Application of α-N-acetylgalactosaminidase and α-galactosidase in AB to O red blood cells conversion. | Gao, H., et al. 2013. Artif Cells Nanomed Biotechnol. 41: 32-6. PMID: 23030311
- Ligand and pathogen specificity of the Atlantic salmon serum C-type lectin. | Uribe, E., et al. 2013. Biochim Biophys Acta. 1830: 2129-38. PMID: 23032861
- Isolation of fucosyltransferase-producing bacteria from marine environments. | Kajiwara, H., et al. 2012. Microbes Environ. 27: 515-8. PMID: 23100020
- Involvement of soil bacteria in ABO blood mistyping. | Takada, N., et al. 2015. Leg Med (Tokyo). 17: 128-33. PMID: 25464834
- The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium perfringens. | Noach, I., et al. 2016. J Mol Biol. 428: 3253-3265. PMID: 27038508
- Discrimination of rat Brunner's gland carbohydrate antigens by site-specific monoclonal antibodies. | Chimuro, T., et al. 2016. Carbohydr Res. 432: 76-82. PMID: 27454489
- Enzymatic Conversion of RBCs by α-N-Acetylgalactosaminidase from Spirosoma linguale. | Malinski, TJ. and Singh, H. 2019. Enzyme Res. 2019: 6972835. PMID: 31186954
- Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production. | Hulme, BJ., et al. 2022. PLoS Pathog. 18: e1009828. PMID: 35025955
- Development of a GalNAc-Tyrosine-Specific Monoclonal Antibody and Detection of Tyrosine O-GalNAcylation in Numerous Human Tissues and Cell Lines. | Xia, L., et al. 2022. J Am Chem Soc. 144: 16410-16422. PMID: 36054098
- A subfamily classification to choreograph the diverse activities within glycoside hydrolase family 31. | Arumapperuma, T., et al. 2023. J Biol Chem. 299: 103038. PMID: 36806678
Substrate of:
Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Nitrophenyl N-acetyl-α-D-galactosaminide, 5 mg | sc-214267 | 5 mg | $183.00 | |||
4-Nitrophenyl N-acetyl-α-D-galactosaminide, 25 mg | sc-214267A | 25 mg | $572.00 | |||
4-Nitrophenyl N-acetyl-α-D-galactosaminide, 50 mg | sc-214267B | 50 mg | $1092.00 | |||
4-Nitrophenyl N-acetyl-α-D-galactosaminide, 100 mg | sc-214267C | 100 mg | $1693.00 |