4-Nitroindole-3-carboxaldehyde (CAS 10553-11-4)
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4-Nitroindole-3-carboxaldehyde (4-NIC) is a highly significant organic compound that has undergone extensive examination owing to its diverse range of applications in scientific research. Functioning as a heterocyclic aldehyde, 4-Nitroindole-3-carboxaldehyde is synthesized through the reaction between nitroethane and indole-3-carboxaldehyde. While the precise mechanism of action for 4-Nitroindole-3-carboxaldehyde remains incompletely understood, it is believed that the compound exerts its effects by binding to the active site of enzymes, including cyclooxygenase-2, cytochrome P450, and thromboxane A2 synthase, consequently inhibiting their activity. The binding interaction between 4-Nitroindole-3-carboxaldehyde and the active site of enzymes is conjectured to occur through the formation of hydrogen bonds with specific residues within the active site.
4-Nitroindole-3-carboxaldehyde (CAS 10553-11-4) References
- A family of indoles regulate virulence and Shiga toxin production in pathogenic E. coli. | Bommarius, B., et al. 2013. PLoS One. 8: e54456. PMID: 23372726
- Engineering of a chromogenic enzyme screening system based on an auxiliary indole-3-carboxylic acid monooxygenase. | Časaitė, V., et al. 2019. Microbiologyopen. 8: e00795. PMID: 30666828
- A rhodamine hydrazide–4-nitroindole-3-carboxaldehyde based turn on Hg2+ chemosensor: cytoplasmic live cell imaging, logic gate and memory device applications and computational studies | Rahul Bhowmick, Abu Saleh Musha Islam, Mihir Sasmal, Atul Katarkar & Mahammad Ali. 2018. Journal of Coordination Chemistry. 71: 2065-2081.
- Indole inhibits quorum sensing-dependent phenotypes and virulence of acute hepatopancreatic necrosis disease-causing Vibrio parahaemolyticus | Panida Paopradit, Tittita Aksonkird, Pimonsri Mittraparp-arthorn. 2022. Aquaculture Research. 53: 3586-3597.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Nitroindole-3-carboxaldehyde, 1 g | sc-256811 | 1 g | $124.00 |