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4-N-(2-Aminoethyl)-1-N-Boc-piperazine (CAS 192130-34-0)

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Alternate Names:
1- tert-Butoxycarbonyl-4-(2-aminoethyl)piperazine
CAS Number:
192130-34-0
Molecular Weight:
229.32
Molecular Formula:
C11H23N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-N-(2-Aminoethyl)-1-N-Boc-piperazine is a specialized chemical compound that serves as a pivotal building block in the synthesis of more complex molecules, particularly in the field of organic chemistry and pharmaceutical research. Structurally, this compound is characterized by a piperazine core, which is a cyclic ethyleneamine with a six-membered ring featuring two nitrogen atoms at opposite positions. Attached to this core is an aminoethyl group at the 4-position, enhancing the molecule′s nucleophilic capabilities, and a tert-butoxycarbonyl (Boc) group at the 1-position, serving as a protective group for the nitrogen atom. This specific arrangement allows for selective reactions at the aminoethyl site, making it invaluable for stepwise synthesis where precision and control are paramount. The Boc group, in particular, is for its role in protecting amines during synthesis, as it can be removed under mild acidic conditions without disturbing other sensitive functional groups within the molecule. The versatility and functionalizability of 4-N-(2-Aminoethyl)-1-N-Boc-piperazine make it a cornerstone in the synthesis of a wide array of targeted molecules, facilitating the exploration of novel compounds with potential applications in various fields of chemical research.


4-N-(2-Aminoethyl)-1-N-Boc-piperazine (CAS 192130-34-0) References

  1. A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists.  |  McKinnell, RM., et al. 2009. J Med Chem. 52: 5330-43. PMID: 19663444
  2. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy.  |  Devisscher, L., et al. 2018. J Med Chem. 61: 10126-10140. PMID: 30354101
  3. Discovery of a Small Molecule Inhibitor of Human Adenovirus Capable of Preventing Escape from the Endosome.  |  Xu, J., et al. 2021. Int J Mol Sci. 22: PMID: 33562748

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-N-(2-Aminoethyl)-1-N-Boc-piperazine, 1 g

sc-267667
1 g
$82.00

4-N-(2-Aminoethyl)-1-N-Boc-piperazine, 5 g

sc-267667A
5 g
$122.00

4-N-(2-Aminoethyl)-1-N-Boc-piperazine, 10 g

sc-267667B
10 g
$204.00

4-N-(2-Aminoethyl)-1-N-Boc-piperazine, 25 g

sc-267667C
25 g
$403.00

4-N-(2-Aminoethyl)-1-N-Boc-piperazine, 100 g

sc-267667D
100 g
$1132.00