4-Methylumbelliferyl sulfate, potassium salt CAS: 15220-11-8
MF: C10H7O6S•K
MW: 294.32
A fluorogenic substrate for the determination of sulfatase.

4-Methylumbelliferyl sulfate, potassium salt (CAS 15220-11-8)

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Alternate Names: Potassium 4-methylumbelliferyl sulfate
Application: 4-Methylumbelliferyl sulfate, potassium salt is a fluorogenic substrate for the determination of sulfatase
CAS Number: 15220-11-8
Molecular Weight: 294.32
Molecular Formula: C10H7O6S•K
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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4-Methylumbelliferyl sulfate, potassium salt is a coumarin derivative and highly sensitive fluorescent substrate for monitoring aryl sulfatase activity. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. This compound is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. Use of this compound in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors.


References

1. Best, M.D., et al. 2004. Chembiochem. 5: 811-819. PMID: 15174164

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (20mM upper limit), and DMSO (30 mg/ml).
Storage :
Store at -20° C
Melting Point :
287-290° C
Fluoresence :
λex 334 nm, λem 370 nm (pH 10.4); λex 360 nm, λem 449 nm (Reaction products)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5044226
MDL Number :
MFCD00016970
EC Number :
239-272-2
Beilstein Registry :
3803203
SMILES :
CC1=CC(=O)OC2=C1C=CC(=C2)OS(=O)(=O)[O-].[K+]

Download SDS (MSDS)

Certificate of Analysis

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