4-Methylumbelliferyl sulfate, potassium salt is a coumarin derivative and highly sensitive fluorescent substrate for monitoring aryl sulfatase activity. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. This compound is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. Use of this compound in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors.
1. Best, M.D., et al. 2004. Chembiochem. 5: 811-819. PMID: 15174164
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