Molecular structure of 4-Methylumbelliferyl sulfate, potassium salt, CAS Number: 15220-11-8
4-Methylumbelliferyl sulfate, potassium salt (CAS 15220-11-8)
Alternate Names:
Potassium 4-methylumbelliferyl sulfate
Application:
4-Methylumbelliferyl sulfate, potassium salt is a fluorogenic substrate for the determination of sulfatase
CAS Number:
15220-11-8
Molecular Weight:
294.32
Molecular Formula:
C10H7O6S•K
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Methylumbelliferyl sulfate, potassium salt is a coumarin derivative and highly sensitive fluorescent substrate for monitoring aryl sulfatase activity. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. This compound is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. Use of this compound in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors.
4-Methylumbelliferyl sulfate, potassium salt (CAS 15220-11-8) References
- Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening. | Best, MD., et al. 2004. Chembiochem. 5: 811-9. PMID: 15174164
- A fluorogenic substrate for the continuous assaying of aryl sulfatases. | Ahmed, V., et al. 2005. Anal Biochem. 340: 80-8. PMID: 15802133
- Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat. | Zamek-Gliszczynski, MJ., et al. 2006. J Pharmacol Exp Ther. 319: 459-67. PMID: 16857726
- Futile cycling of a sulfate conjugate by isolated hepatocytes. | Kauffman, FC., et al. 1991. Mol Pharmacol. 39: 414-20. PMID: 2005878
- Fluorescence assay for protein post-translational tyrosine sulfation. | Chen, BH., et al. 2013. Anal Bioanal Chem. 405: 1425-9. PMID: 23161068
- Specific detection of the pesticide chlorpyrifos by a sensitive genetic-based whole cell biosensor. | Whangsuk, W., et al. 2016. Anal Biochem. 493: 11-3. PMID: 26452613
- Validation of a probe for assessing deconjugation of glucuronide and sulfate phase II metabolites assayed through LC-MS/MS in biological matrices. | Grignon, C., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1061-1062: 72-78. PMID: 28710970
- Hydrolysis of 4-methylumbelliferyl sulfate in periportal and pericentral areas of the liver lobule. | Anundi, I., et al. 1987. Arch Toxicol. 60: 69-72. PMID: 3619646
- Effect of protein binding on 4-methylumbelliferyl sulfate desulfation kinetics in perfused rat liver. | Chiba, M. and Pang, KS. 1993. J Pharmacol Exp Ther. 266: 492-9. PMID: 8355186
- Futile cycling between 4-methylumbelliferone and its conjugates in perfused rat liver. | Ratna, S., et al. 1993. Hepatology. 17: 838-53. PMID: 8491453
- Uptake of sulfate conjugates by isolated rat hepatocytes. | Hassen, AM., et al. 1996. Drug Metab Dispos. 24: 792-8. PMID: 8818578
- Carrier-mediated entry of 4-methylumbelliferyl sulfate: characterization by the multiple-indicator dilution technique in perfused rat liver. | Chiba, M., et al. 1998. Hepatology. 27: 134-46. PMID: 9425929
Substrate of:
Fluorogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Methylumbelliferyl sulfate, potassium salt, 500 mg | sc-206917 | 500 mg | $152.00 | |||
4-Methylumbelliferyl sulfate, potassium salt, 1 g | sc-206917A | 1 g | $275.00 |