Molecular structure of 4-Methylumbelliferyl α-L-Idopyranosiduronic acid, Sodium Salt, CAS Number: 89157-94-8
4-Methylumbelliferyl α-L-Idopyranosiduronic acid, Sodium Salt (CAS 89157-94-8)
Application:
4-Methylumbelliferyl α-L-Idopyranosiduronic acid, Sodium Salt is a fluorogenic substrate in the assay of α-L-Iduronidase
CAS Number:
89157-94-8
Purity:
≥98%
Molecular Weight:
374.27
Molecular Formula:
C16H15NaO9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Methylumbelliferyl α-L-idopyranosiduronic acid is a fluorogenic substrate for α-L-iduronidase. Active α-L-iduronidase cleaves the Methylumbelliferyl moiety from the synthetic substrate, which results in release of a fluorescent signal. The 4-methylumbelliferone core is a widely used fluorophore that emits blue light when excited by ultraviolet (UV) light, but its fluorescence is quenched when attached to the α-L-Idopyranosiduronic acid. The reaction is stopped by the addition of sodium carbonate.
4-Methylumbelliferyl α-L-Idopyranosiduronic acid, Sodium Salt (CAS 89157-94-8) References
- Direct assay of iduronate-2-sulfatase for Hunter disease using UPLC-tandem mass spectrometry and fluorogenic substrate. | Lee, K., et al. 2015. Clin Biochem. 48: 1350-3. PMID: 26297117
- Newborn screening for mucopolysaccharidoses: Measurement of glycosaminoglycans by LC-MS/MS. | Stapleton, M., et al. 2020. Mol Genet Metab Rep. 22: 100563. PMID: 31956510
- Implementation of an Affordable Method for MPS Diagnosis from Urine Screening to Enzymatic Confirmation: Results of a Pilot Study in Morocco. | Fdil, N., et al. 2020. Clin Lab. 66: PMID: 32162878
Substrate of:
Enzyme, and Fluorogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Methylumbelliferyl α-L-Idopyranosiduronic acid, Sodium Salt, 5 mg | sc-216951 | 5 mg | $343.00 |