4-Methylumbelliferyl α-L-Idopyranosiduronic Acid, Cyclohexylammonium Salt (CAS 66895-33-8)
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4-Methylumbelliferyl α-L-idopyranosiduronic acid, cyclohexylammonium salt is a fluorescent substrate. It is for investigating the functionality of various enzymes, those engaged in carbohydrate metabolism. It serves as a substrate for assessing the activity of iduronidase and heparan sulfate sulfatase. The mechanism of action of 4-Methylumbelliferyl α-L-idopyranosiduronic acid, cyclohexylammonium salt involves the hydrolysis of the glycosidic bond between the iduronic acid and the 4-methylumbelliferyl group by the enzyme under investigation. Consequently, the 4-methylumbelliferyl group is liberated, and when excited by light of a specific wavelength, it fluoresces. The resulting fluorescence can be quantified to determine the enzyme′s activity.
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid, Cyclohexylammonium Salt (CAS 66895-33-8) References
- Biodistribution and pharmacodynamics of recombinant human alpha-L-iduronidase (rhIDU) in mucopolysaccharidosis type I-affected cats following multiple intrathecal administrations. | Vite, CH., et al. 2011. Mol Genet Metab. 103: 268-74. PMID: 21482164
- Hurler's syndrome, an -L-iduronidase deficiency. | Matalon, R. and Dorfman, A. 1972. Biochem Biophys Res Commun. 47: 959-64. PMID: 4260316
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid, Cyclohexylammonium Salt, 1 mg | sc-220961A | 1 mg | $166.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid, Cyclohexylammonium Salt, 2 mg | sc-220961B | 2 mg | $299.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid, Cyclohexylammonium Salt, 5 mg | sc-220961 | 5 mg | $475.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid, Cyclohexylammonium Salt, 25 mg | sc-220961C | 25 mg | $1699.00 |