4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt (CAS 1045020-74-3)
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4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt is a fluorogenic substrate used in biochemistry research for the assay of enzyme activity, specifically α-L-iduronidase. This enzyme is significant in the degradation of glycosaminoglycans, and the compound is used in enzyme activity assays to measure the breakdown of its glycosidic bond. Upon hydrolysis by α-L-iduronidase, the compound releases a highly fluorescent 4-methylumbelliferone moiety, which can be quantified using a fluorometer. This property makes it particularly useful for studying the kinetics of the enzyme and for understanding lysosomal storage diseases where α-L-iduronidase activity is deficient or absent. Additionally, in environmental research, this compound aids in the monitoring of microbial degradation of sulfated polysaccharides in various ecosystems. The compound′s ability to act as a specific substrate for the enzyme under investigation allows for high-throughput screening and characterization of α-L-iduronidase variants and potential modulators.
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt (CAS 1045020-74-3) References
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- Direct assay of iduronate-2-sulfatase for Hunter disease using UPLC-tandem mass spectrometry and fluorogenic substrate. | Lee, K., et al. 2015. Clin Biochem. 48: 1350-3. PMID: 26297117
- Targeting Brain Disease in MPSII: Preclinical Evaluation of IDS-Loaded PLGA Nanoparticles. | Rigon, L., et al. 2019. Int J Mol Sci. 20: PMID: 31022913
- Newborn screening for mucopolysaccharidoses: Measurement of glycosaminoglycans by LC-MS/MS. | Stapleton, M., et al. 2020. Mol Genet Metab Rep. 22: 100563. PMID: 31956510
- Characterization of a HIR-Fab-IDS, Novel Iduronate 2-Sulfatase Fusion Protein for the Treatment of Neuropathic Mucopolysaccharidosis Type II (Hunter Syndrome). | Gusarova, VD., et al. 2023. BioDrugs. 37: 375-395. PMID: 37014547
- Frequency of iduronate-2-sulfatase gene variants detected in newborn screening for mucopolysaccharidosis type II in Japan. | Hattori, Y., et al. 2023. Mol Genet Metab Rep. 37: 101003. PMID: 38053932
- Hurler's syndrome, an -L-iduronidase deficiency. | Matalon, R. and Dorfman, A. 1972. Biochem Biophys Res Commun. 47: 959-64. PMID: 4260316
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 0.5 mg | sc-210122E | 0.5 mg | $367.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 1 mg | sc-210122 | 1 mg | $924.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 1.5 mg | sc-210122F | 1.5 mg | $1061.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 1.5 mg | sc-210122F-CW | 1.5 mg | $1224.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 2 mg | sc-210122G | 2 mg | $1403.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 5 mg | sc-210122A | 5 mg | $3468.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 5 mg | sc-210122A-CW | 5 mg | $3500.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 10 mg | sc-210122B | 10 mg | $5778.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 10 mg | sc-210122B-CW | 10 mg | $5778.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 50 mg | sc-210122C | 50 mg | $20400.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 50 mg | sc-210122C-CW | 50 mg | $2142.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 100 mg | sc-210122D | 100 mg | $39576.00 | |||
4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 100 mg | sc-210122D-CW | 100 mg | $39576.00 |