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4-Methylumbelliferyl α-D-glucopyranoside (CAS 17833-43-1)

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Alternate Names:
4-Methylumbelliferyl-α-D-glucoside
Application:
4-Methylumbelliferyl α-D-glucopyranoside is a fluorogenic β-glucosidase substrate
CAS Number:
17833-43-1
Molecular Weight:
338.31
Molecular Formula:
C16H18O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Methylumbelliferyl α-D-glucopyranoside is known for its role in enzymology. This compound is often used as a substrate in assays to detect, quantify, and study the activity of specific enzymes, such as α-glucosidases. Upon enzymatic cleavage, 4-Methylumbelliferyl α-D-glucopyranoside releases 4-methylumbelliferone, a fluorescent compound that emits blue light. This fluorescence can be easily detected and measured, providing a sensitive method for monitoring enzyme activity in real-time. This property makes it invaluable in research laboratories for conducting enzymatic assays, studying carbohydrate metabolism, and investigating the mechanisms of action of various enzymes. In industrial applications, 4-Methylumbelliferyl α-D-glucopyranoside can be employed in the development of biotechnological products and processes, such as in the screening of compounds that can modulate enzyme activity.


4-Methylumbelliferyl α-D-glucopyranoside (CAS 17833-43-1) References

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  2. Purification and biochemical characterisation of a membrane-bound alpha-glucosidase from the parasite Entamoeba histolytica.  |  Bravo-Torres, JC., et al. 2004. Int J Parasitol. 34: 455-62. PMID: 15013735
  3. Diagnosis of Pompe's disease in cultured skin fibroblasts and primary amniotic fluid cells using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate.  |  Butterworth, J. and Droadhead, DM. 1977. Clin Chim Acta. 78: 335-42. PMID: 18303
  4. Alpha-glucosidase inhibition assay in an enzyme-immobilized amino-microplate.  |  Matsui, T., et al. 2009. Anal Sci. 25: 559-62. PMID: 19359799
  5. A new resorufin-based alpha-glucosidase assay for high-throughput screening.  |  Motabar, O., et al. 2009. Anal Biochem. 390: 79-84. PMID: 19371716
  6. Purification and partial biochemical characterization of a membrane-bound type II-like α-glucosidase from the yeast morphotype of Sporothrix schenckii.  |  Torres-Rodríguez, BI., et al. 2012. Antonie Van Leeuwenhoek. 101: 313-22. PMID: 21927828
  7. Multiplex newborn screening for Pompe, Fabry, Hunter, Gaucher, and Hurler diseases using a digital microfluidic platform.  |  Sista, RS., et al. 2013. Clin Chim Acta. 424: 12-8. PMID: 23660237
  8. Late onset form of Pompe disease.  |  Mattosova, S., et al. 2015. Bratisl Lek Listy. 116: 502-5. PMID: 26350092
  9. Enhanced Colorimetric Differentiation between Staphylococcus aureus and Pseudomonas aeruginosa Using a Shape-Encoded Sensor Hydrogel.  |  Jia, Z., et al. 2020. ACS Appl Bio Mater. 3: 4398-4407. PMID: 35025438
  10. Pompe's disease: diagnosis in kidney and leucocytes using 4-methylumbelliferyl-alpha-D-glucopyranoside.  |  Broadhead, DM. and Butterworth, J. 1978. Clin Genet. 13: 504-10. PMID: 352582
  11. alpha-Glucosidase in Pompe's disease.  |  Broadhead, DM. and Butterworth, J. 1978. J Inherit Metab Dis. 1: 153-4. PMID: 41974
  12. Kinetics of interaction of some alpha- and beta-D-monosaccharides with concanavalin A.  |  Farina, RD. and Wilkins, RG. 1980. Biochim Biophys Acta. 631: 428-38. PMID: 6893288
  13. Purification and characterization of glucosidase II, an endoplasmic reticulum hydrolase involved in glycoprotein biosynthesis.  |  Burns, DM. and Touster, O. 1982. J Biol Chem. 257: 9990-10000. PMID: 7050114

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Methylumbelliferyl α-D-glucopyranoside, 250 mg

sc-280451
250 mg
$156.00

4-Methylumbelliferyl α-D-glucopyranoside, 500 mg

sc-280451A
500 mg
$287.00

4-Methylumbelliferyl α-D-glucopyranoside, 1 g

sc-280451B
1 g
$431.00