Molecular structure of 4-Methylumbelliferyl 6-Sulfo-2-acetamido-2-deoxy-β-D-glucopyranoside Potassium Salt, CAS Number: 210357-38-3
4-Methylumbelliferyl 6-Sulfo-2-acetamido-2-deoxy-β-D-glucopyranoside Potassium Salt (CAS 210357-38-3)
Alternate Names:
4-Methylumbelliferyl 6-Sulfo-2-acetamido-2-deoxy-β-D-glucopyranoside Potassium Salt is also known as MUGS.
Application:
4-Methylumbelliferyl 6-Sulfo-2-acetamido-2-deoxy-β-D-glucopyranoside Potassium Salt is a fluorogenic substrate of GNS.
CAS Number:
210357-38-3
Purity:
98%
Molecular Weight:
497.51
Molecular Formula:
C18H20KNO11S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
4-Methylumbelliferyl 6-Sulfo-2-acetamido-2-deoxy-α-D-glucopyranoside, Potassium Salt is used as a substrate for the detection and quantification of enzymes such as β-glucuronidase and β-galactosidase. When these enzymes are present, they cleave the substrate, releasing the fluorescent compound 4-methylumbelliferone. This allows for the measurement of enzyme activity through the detection of fluorescence, providing a sensitive and specific method for the analysis of these enzymes in various biological samples. The mechanism of action involves the enzymatic hydrolysis of the substrate, leading to the release of the fluorescent product. 4-Methylumbelliferyl 6-Sulfo-2-Acetamido-2-Deoxy-Å-D-Glucopyranoside, Potassium Salt plays a functional role in enabling the measurement of enzyme activity, contributing to the understanding of biological processes and pathways. Its use in experimental applications allows for the investigation of enzyme function and regulation.
4-Methylumbelliferyl 6-Sulfo-2-acetamido-2-deoxy-β-D-glucopyranoside Potassium Salt (CAS 210357-38-3) References
- Plasmid-based gene transfer ameliorates visceral storage in a mouse model of Sandhoff disease. | Yamaguchi, A., et al. 2003. J Mol Med (Berl). 81: 185-93. PMID: 12682727
- Enzymatic properties and subcellular localization of Arabidopsis beta-N-acetylhexosaminidases. | Strasser, R., et al. 2007. Plant Physiol. 145: 5-16. PMID: 17644627
- Gene transfer corrects acute GM2 gangliosidosis--potential therapeutic contribution of perivascular enzyme flow. | Cachón-González, MB., et al. 2012. Mol Ther. 20: 1489-500. PMID: 22453766
- Therapeutic response in feline sandhoff disease despite immunity to intracranial gene therapy. | Bradbury, AM., et al. 2013. Mol Ther. 21: 1306-15. PMID: 23689599
- Clinical,biochemical and molecular analysis of five Chinese patients with Sandhoff disease. | Zhang, W., et al. 2016. Metab Brain Dis. 31: 861-7. PMID: 27021291
- Novel diagnostic cerebrospinal fluid biomarkers for pathologic subtypes of frontotemporal dementia identified by proteomics. | Teunissen, CE., et al. 2016. Alzheimers Dement (Amst). 2: 86-94. PMID: 27239539
- Direct Intracranial Injection of AAVrh8 Encoding Monkey β-N-Acetylhexosaminidase Causes Neurotoxicity in the Primate Brain. | Golebiowski, D., et al. 2017. Hum Gene Ther. 28: 510-522. PMID: 28132521
- Use of 4-methylumbelliferyl-6-sulpho-2-acetamido-2-deoxy-beta- D-glucopyranoside for prenatal diagnosis of Tay-Sachs disease using chorionic villi. | Grebner, EE. and Wenger, DA. 1987. Prenat Diagn. 7: 419-23. PMID: 2958791
- Prenatal Diagnosis of Tay-Sachs Disease. | Zhang, J., et al. 2019. Methods Mol Biol. 1885: 233-250. PMID: 30506202
- GM2-GM3 gangliosides ratio is dependent on GRP94 through down-regulation of GM2-AP cofactor in brain metastasis cells. | Bedia, C., et al. 2019. Sci Rep. 9: 14241. PMID: 31578452
- Pronounced Therapeutic Benefit of a Single Bidirectional AAV Vector Administered Systemically in Sandhoff Mice. | Lahey, HG., et al. 2020. Mol Ther. 28: 2150-2160. PMID: 32592687
- Synthesis of 4-methylumbelliferyl-beta-D-N-acetylglucosamine-6-sulfate and its use in classification of GM2 gangliosidosis genotypes. | Bayleran, J., et al. 1984. Clin Chim Acta. 143: 73-89. PMID: 6239713
- A fluorimetric enzyme assay for the diagnosis of Sanfilippo disease type D (MPS IIID). | He, W., et al. 1993. J Inherit Metab Dis. 16: 935-41. PMID: 8127069
- Identification of domains in human beta-hexosaminidase that determine substrate specificity. | Pennybacker, M., et al. 1996. J Biol Chem. 271: 17377-82. PMID: 8663217
Substrate of:
Enzyme, Fluorogenic, GNS, and HEXA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Methylumbelliferyl 6-Sulfo-2-acetamido-2-deoxy-β-D-glucopyranoside Potassium Salt, 1 mg | sc-223640 | 1 mg | $146.00 | |||
4-Methylumbelliferyl 6-Sulfo-2-acetamido-2-deoxy-β-D-glucopyranoside Potassium Salt, 25 mg | sc-223640A | 25 mg | $343.00 | |||
4-Methylumbelliferyl 6-Sulfo-2-acetamido-2-deoxy-β-D-glucopyranoside Potassium Salt, 100 mg | sc-223640B | 100 mg | $519.00 |