Molecular structure of 4-Methylumbelliferone sodium salt, CAS Number: 5980-33-6
4-Methylumbelliferone sodium salt (CAS 5980-33-6)
Alternate Names:
Cantabiline sodium; 7-Hydroxy-4-methylcoumarin
Application:
4-Methylumbelliferone sodium salt is a selective inhibitor of Hyaluronan (HA) synthesis
CAS Number:
5980-33-6
Purity:
≥98%
Molecular Weight:
198.15
Molecular Formula:
C10H7O3•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Methylumbelliferone sodium salt is a selective inhibitor of Hyaluronan (HA) synthesis. HA is a major component in the metastasis of malignant tumors. Studies indicate that in the presence of 4-Methylumbelliferone sodium salt cell proliferation, migration, and growth are inhibited, while apoptosis is induced. In addition, the motility and cell growth was inhibited in fibroblast cell line NIH/3T3 (sc-2210). 4-Methylumbelliferone sodium salt is thought to function as an inhibitor via the depletion of UDP-glucuronic acid, the common substrate for HA synthesis. It is also believed that 4-Methylumbelliferone sodium salt can suppress the expression of HA-synthase.
4-Methylumbelliferone sodium salt (CAS 5980-33-6) References
- Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase. | Clarkin, CE., et al. 2011. Matrix Biol. 30: 163-8. PMID: 21292001
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- Antioxidant Activities of 4-Methylumbelliferone Derivatives. | Al-Majedy, YK., et al. 2016. PLoS One. 11: e0156625. PMID: 27243231
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- 4-Methylumbelliferone fused oxazole thioether derivatives: synthesis, characterization and antifungal activities. | Xu, HL., et al. 2022. Nat Prod Res. 36: 707-713. PMID: 32757631
- 4-Methylumbelliferone promotes the migration and odontogenetic differentiation of human dental pulp stem cells exposed to lipopolysaccharide in vitro. | Chen, W., et al. 2021. Cell Biol Int. 45: 1415-1422. PMID: 33675275
- 4-Methylumbelliferone Attenuates Macrophage Invasion and Myocardial Remodeling in Pressure-Overloaded Mouse Hearts. | Hackert, K., et al. 2021. Hypertension. 77: 1918-1927. PMID: 33745300
- 4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication. | Saga, R., et al. 2021. Sci Rep. 11: 8258. PMID: 33859324
- 4-Methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy for chronic prostatitis. | Chen, J., et al. 2021. Prostate. 81: 1078-1090. PMID: 34320251
- 4-Methylumbelliferone suppresses catabolic activation in anterior cruciate ligament-derived cells via a mechanism independent of hyaluronan inhibition. | Idota, M., et al. 2021. J Orthop Surg Res. 16: 507. PMID: 34404442
- Glycosylated 4-methylumbelliferone as a targeted therapy for hepatocellular carcinoma. | Weiz, G., et al. 2022. Liver Int. 42: 444-457. PMID: 34800352
- Oral treatment of 4-methylumbelliferone reduced perineuronal nets and improved recognition memory in mice. | Dubisova, J., et al. 2022. Brain Res Bull. 181: 144-156. PMID: 35066096
- Dual targeting nanoparticles based on hyaluronic and folic acids as a promising delivery system of the encapsulated 4-Methylumbelliferone (4-MU) against invasiveness of lung cancer in vivo and in vitro. | Essa, ML., et al. 2022. Int J Biol Macromol. 206: 467-480. PMID: 35202638
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Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Methylumbelliferone sodium salt, 10 g | sc-214255 | 10 g | $155.00 | |||
4-Methylumbelliferone sodium salt, 25 g | sc-214255A | 25 g | $315.00 |