Molecular structure of 4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanone, CAS Number: 76014-82-9
4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanone (CAS 76014-82-9)
Alternate Names:
4-(Methylnitrosoamino)-1-(1-oxido-3-pyridinyl)-1-butanone; NNK-N-Oxide
Application:
4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanone is a tobacco-specific nitrosamine NNK metabolite
CAS Number:
76014-82-9
Molecular Weight:
223.23
Molecular Formula:
C10H13N3O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tobacco-specific nitrosamine NNK metabolite.
4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanone (CAS 76014-82-9) References
- The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice. | Brown, BG., et al. 2001. Chem Biol Interact. 138: 125-35. PMID: 11672696
- Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by inducible and constitutive cytochrome P450 enzymes in rats. | Guo, Z., et al. 1992. Arch Biochem Biophys. 298: 279-86. PMID: 1524438
- Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. | Hecht, SS., et al. 2007. Chem Res Toxicol. 20: 543-9. PMID: 17291014
- Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cytochrome P450IIB1 in a reconstituted system. | Guo, Z., et al. 1991. Carcinogenesis. 12: 2277-82. PMID: 1747927
- Inhibition of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by dietary benzaldehydes. | Morse, MA., et al. 1995. Cancer Lett. 97: 255-61. PMID: 7497471
- Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by hamster, mouse and rat intestine: relevance of species differences. | Schulze, J., et al. 1996. Carcinogenesis. 17: 1093-9. PMID: 8640918
- Simultaneous solid-phase extraction and gas chromatographic-mass spectrometric determination of hemoglobin adducts from tobacco-specific nitrosamines and aromatic amines. | Kutzer, C., et al. 1997. J Chromatogr Sci. 35: 1-6. PMID: 8989869
- Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen. | Carmella, SG., et al. 1997. Cancer Epidemiol Biomarkers Prev. 6: 113-20. PMID: 9037562
- Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes. | Smith, TJ., et al. 1997. Carcinogenesis. 18: 1577-84. PMID: 9276633
- Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in isolated rat lung and liver. | Schrader, E., et al. 1998. Naunyn Schmiedebergs Arch Pharmacol. 357: 336-43. PMID: 9550307
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanone, 10 mg | sc-214215 | 10 mg | $312.00 |