Molecular structure of 4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol, CAS Number: 85352-99-4
4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol (CAS 85352-99-4)
Alternate Names:
NNAL-N-Oxide
CAS Number:
85352-99-4
Molecular Weight:
225.24
Molecular Formula:
C10H15N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol is a metabolite of NNK, which is a tobacco-specific nitrosamine.
4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol (CAS 85352-99-4) References
- Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse. | Upadhyaya, P., et al. 1999. Carcinogenesis. 20: 1577-82. PMID: 10426810
- Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: stereoselective metabolism and tissue distribution. | Wu, Z., et al. 2002. Carcinogenesis. 23: 171-9. PMID: 11756238
- Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). | Zimmerman, CL., et al. 2004. Carcinogenesis. 25: 1237-42. PMID: 14988218
- Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. | Hecht, SS., et al. 2007. Chem Res Toxicol. 20: 543-9. PMID: 17291014
- Synthesis of 4-[2-aminoethyl(nitrosamino)]-1-pyridin-3-yl-butan-1-one, a new NNK hapten for the induction of N-nitrosamine-specific antibodies. | Prodhomme, EJ., et al. 2007. Bioconjug Chem. 18: 2045-53. PMID: 17939731
- Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung tissue from mouse, rat, hamster, and man. | Richter, E., et al. 2009. Chem Res Toxicol. 22: 1008-17. PMID: 19408892
- Toxicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in early development: A wide-scope metabolomics assay in zebrafish embryos. | Merino, C., et al. 2022. J Hazard Mater. 429: 127746. PMID: 35086039
- Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites. | Hecht, SS., et al. 1993. Carcinogenesis. 14: 229-36. PMID: 8435864
- Simultaneous solid-phase extraction and gas chromatographic-mass spectrometric determination of hemoglobin adducts from tobacco-specific nitrosamines and aromatic amines. | Kutzer, C., et al. 1997. J Chromatogr Sci. 35: 1-6. PMID: 8989869
- Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in isolated rat lung and liver. | Schrader, E., et al. 1998. Naunyn Schmiedebergs Arch Pharmacol. 357: 336-43. PMID: 9550307
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol, 5 mg | sc-206777 | 5 mg | $330.00 |