4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (CAS 76014-81-8)

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol, scientifically known as NNK, is a tobacco-specific nitrosamine belonging to the nitrosamine family. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol is primarily formed during the combustion of tobacco products, resulting in its presence in the smoke. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol plays a role in scientific investigations due to its carcinogenic properties. Researchers utilize 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol to explore the impact of tobacco smoke on human cells and tissues, as well as to delve into the mechanisms underlying carcinogenesis. Furthermore, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol serves as useful in studying the effects of tobacco smoke on the immune system. Operating as a potent carcinogen, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol exerts its influence by binding to DNA and inducing mutations. Metabolized by cytochrome P450 enzymes, it undergoes conversion into its active form, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK-N-oxide). Subsequently, NNK-N-oxide binds to DNA, leading to mutations that can initiate cancer development. This characteristic makes 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol a significant subject of research and investigation.