4-Methyl-DL-tryptophan (CAS 1954-45-6)
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4-Methyl-DL-tryptophan is frequently in biochemistry to investigate the metabolism of amino acids and their derivatives. 4-Methyl-DL-tryptophan serves for studying the tryptophan metabolic pathways, including the kynurenine pathway, which is significant for understanding cellular responses to stress and immune regulation. Applications involving 4-Methyl-DL-tryptophan also focuses on its effects on enzymes involved in tryptophan catabolism, such as indoleamine 2,3-dioxygenase (IDO). This is for developing a deeper understanding of how modifications to the tryptophan structure influence enzyme activity and metabolic pathways. 4-Methyl-DL-tryptophan is in studies aimed at elucidating the role of modified amino acids in protein synthesis and function, providing insights into the molecular mechanisms of biological regulation and complexity.
4-Methyl-DL-tryptophan (CAS 1954-45-6) References
- Biosynthesis of the actinomycin chromophore. Influence of alpha-, 4-, 5-, and 6-methyl-DL-tryptophan on actinomycin synthesis. | SIVAK, A. and KATZ, E. 1962. Biochim Biophys Acta. 62: 80-90. PMID: 13913519
- Regulation of early reactions in the biosynthesis of tryptophan in Neurospora crassa. | LESTER, G. 1963. J Bacteriol. 85: 468-75. PMID: 13929917
- Substrate promiscuity of the cyclic dipeptide prenyltransferases from Aspergillus fumigatus (section sign). | Zou, H., et al. 2009. J Nat Prod. 72: 44-52. PMID: 19113967
- Regiospecific benzylation of tryptophan and derivatives catalyzed by a fungal dimethylallyl transferase. | Liebhold, M. and Li, SM. 2013. Org Lett. 15: 5834-7. PMID: 24188078
- A 7-dimethylallyl tryptophan synthase from a fungal Neosartorya sp.: biochemical characterization and structural insight into the regioselective prenylation. | Miyamoto, K., et al. 2014. Bioorg Med Chem. 22: 2517-28. PMID: 24657051
- A new member of the DMATS superfamily from Aspergillus niger catalyzes prenylations of both tyrosine and tryptophan derivatives. | Fan, A., et al. 2014. Appl Microbiol Biotechnol. 98: 10119-29. PMID: 24970457
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- Interactions between amino acid transport systems in Neurospora crassa. | Sanchez, S., et al. 1972. J Bacteriol. 112: 276-84. PMID: 4263403
- Tryptophan metabolism and kynureninase induction in mutants of Neurospora crassa resistant to 4-methyl-tryptophan. | Turner, JR. 1973. J Bacteriol. 115: 640-7. PMID: 4269379
- Regulation of enzymes involved in the conversion of tryptophan to nicotinamide adenine dinucleotide in a colorless strain of Xanthomonas pruni. | Brown, AT. and Wagner, C. 1970. J Bacteriol. 101: 456-63. PMID: 4313053
- In vivo regulation of intermediate reactions in the pathway of tryptophan biosynthesis in Neurospora crassa. | Lester, G. 1968. J Bacteriol. 96: 1768-73. PMID: 5726311
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- Prenylation of tyrosine and derivatives by a tryptophan C7-prenyltransferase | Fan, A., & Li, S. M. 2014. Tetrahedron Letters. 55(37): 5199-5202.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Methyl-DL-tryptophan, 100 mg | sc-280446 | 100 mg | $108.00 | |||
4-Methyl-DL-tryptophan, 250 mg | sc-280446A | 250 mg | $153.00 |