4-Methyl-5-thiazoleethanol (CAS 137-00-8)

4-Methyl-5-thiazoleethanol is utilized in the synthesis of novel HldE kinase inhibitors used against gram-negative bacteria. It is also used in the synthesis of potential antimalarial agents derived from bis-thiazolium analogues. This compound was originally isolated from the ether-soluble alkaloidal fraction of Panax ginseng. 4-Methyl-5-thiazoleethanol demonstrates the ability to inhibit the growth of certain wild-type bacterial strains. By binding to the bacterial cell membrane, it prevents the transport of nutrients into the cell, ultimately leading to a decrease in ATP synthesis and metabolic disorders. Additionally, 4-Methyl-5-thiazoleethanol inhibts caproic acid oxidation, potentially impacting cytosolic Ca2+ responses. 4-Methyl-5-thiazoleethanol exhibits a strong affinity for DNA and RNA, allowing it to be a good candidate for biochemical experiments involving these biomolecules. The specific binding site of 4-Methyl-5-thiazoleethanol is yet to be determined, it is hypothesized that this compound interacts with nucleic acids through electrostatic interactions or hydrogen bonding.