Date published: 2026-2-2

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4-Methyl-1,2,4-triazoline-3,5-dione (CAS 13274-43-6)

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Alternate Names:
4-Mtad
Application:
CAS Number:
13274-43-6
Molecular Weight:
113.07
Molecular Formula:
C3H3N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Methyl-1,2,4-triazoline-3,5-dione is used at trace levels in the partial elucidation of Trichogramma putative sex pheromones. It is a heterocyclic compound containing a triazole ring and a nitro group that has gained significant attention in scientific research due to its unique properties and potential applications. It has been studied extensively for its potential applications in various scientific fields, particularly as a reagent in organic synthesis. Its mild oxidizing properties make it useful for converting alcohols to aldehydes or ketones, and it has also been used in the synthesis of various heterocyclic compounds.


4-Methyl-1,2,4-triazoline-3,5-dione (CAS 13274-43-6) References

  1. Isotope effects and syn selectivity in the ene reaction of triazolinedione with conjugated enones: aziridinium imide or an open intermediate mechanism?  |  Vassilikogiannakis, G., et al. 2000. Org Lett. 2: 2245-8. PMID: 10930254
  2. Stereochemistry in the reaction of 4-methyl-1,2,4-triazoline-3,5-dione (MTAD) with beta,beta dimethyl-p-methoxystyrene. Are open biradicals the reaction intermediates?  |  Stratakis, M., et al. 2001. J Org Chem. 66: 3682-7. PMID: 11374985
  3. Low-temperature photosensitized oxidation of a guanosine derivative and formation of an imidazole ring-opened product.  |  Sheu, C., et al. 2002. J Am Chem Soc. 124: 3905-13. PMID: 11942827
  4. Efficient method to locate double bond positions in conjugated trienes.  |  Marques, FA., et al. 2004. J Chromatogr A. 1048: 59-65. PMID: 15453419
  5. [Determination of double bond position in conjugated dienes in sex pheromones of Dendrolimus spp].  |  Kong, X., et al. 2004. Se Pu. 22: 97-100. PMID: 15712861
  6. Partial elucidation of Trichogramma putative sex pheromone at trace levels by solid-phase microextraction and gas chromatography-mass spectrometry studies.  |  van Beek, TA., et al. 2005. J Chromatogr A. 1067: 311-21. PMID: 15844537
  7. Sex pheromones of five olethreutine species (Lepidoptera: Tortricidae) associated with the seedlings and fruits of mangrove plants in the Ryukyu Islands, Japan: identification and field evaluation.  |  Vang, le V., et al. 2005. J Chem Ecol. 31: 859-78. PMID: 16124256
  8. (11Z,13E)-Hexadecadien-1-yl acetate: sex pheromone of the grass webworm Herpetogramma licarsisalis-identification, synthesis, and field bioassays.  |  Gibb, AR., et al. 2007. J Chem Ecol. 33: 839-47. PMID: 17334920
  9. Major sex pheromone components of the Australian gum leaf skeletonizer Uraba lugens: (10E,12Z)-hexadecadien-1-yl acetate and (10E,12Z)-hexadecadien-1-ol.  |  Gibb, AR., et al. 2008. J Chem Ecol. 34: 1125-33. PMID: 18679751
  10. Gas chromatography-mass spectrometry of conjugated dienes by derivatization with 4-methyl-1,2,4-triazoline-3,5-dione.  |  Young, DC., et al. 1990. J Chromatogr. 522: 295-302. PMID: 2081754
  11. Improved HRGC separation of cis, trans CLA isomers as Diels-Alder adducts of alkyl esters.  |  Blasi, F., et al. 2011. J Chromatogr Sci. 49: 379-83. PMID: 21549030
  12. Identification and field evaluation of sex pheromone components of the pear barkminer moth, Spulerina astaurota.  |  Do, ND., et al. 2011. J Chem Ecol. 37: 1222-30. PMID: 22113370
  13. Safety of dietary conjugated α-linolenic acid (CLNA) in a neonatal pig model.  |  Castellano, CA., et al. 2014. Food Chem Toxicol. 64: 119-25. PMID: 24291452
  14. π-Extended Rubrenes via Dearomative Annulative π-Extension Reaction.  |  Matsuoka, W., et al. 2023. J Am Chem Soc. 145: 658-666. PMID: 36563098

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Methyl-1,2,4-triazoline-3,5-dione, 250 mg

sc-226730
250 mg
$305.00

4-Methyl-1,2,4-triazoline-3,5-dione, 1 g

sc-226730A
1 g
$965.00