4-Methoxy-17β-estradiol (CAS 26788-23-8)

4-Methoxy-17β-estradiol (4-ME2) is a metabolite of estradiol with intriguing attributes that position it uniquely in the realm of biochemical research, particularly in the study of estrogen receptor dynamics and cellular signaling pathways. This compound acts through a sophisticated mechanism, engaging estrogen receptors with a distinct affinity compared to its parent hormone, estradiol, thereby modulating gene expression in a nuanced manner. Its ability to influence various signaling cascades, beyond the classical genomic pathways typically associated with estrogens, places it at the forefront of studies aiming to elucidate the non-genomic actions of estrogen-like molecules. Importantly, 4-Methoxy-17β-estradiol has been instrumental in advancing our understanding of the delicate interplay between estrogen receptors and cell proliferation processes, making it useful in the exploration of cellular responses to estrogens in diverse biological systems. This compound′s role in research extends to probing the mechanisms underlying estrogen-induced neuroprotection, offering a window into the complex effects of estrogens on neural tissues.