Date published: 2025-9-25

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4-Mercaptophenylboronic acid (CAS 237429-33-3)

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CAS Number:
237429-33-3
Molecular Weight:
153.99
Molecular Formula:
C6H7BO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Mercaptophenylboronic acid, also known as 4-MBA or 4-MPBA, is a boronic acid variant of phenylmercaptan, a compound containing sulfur. It serves as a critical intermediate in the synthesis of various organic compounds, encompassing polymers and pesticides. Apart from that, 4-Mercaptophenylboronic acid is employed in the creation of diverse polymers and acts as a catalyst in organic reactions. It also aids in the production of other compounds like polysulfides, polythioethers, and polysulfones. 4-Mercaptophenylboronic acid finds a multitude of uses in scientific research applications, including the synthesis of organic compounds, catalytic reactions, and polymer production. Furthermore, it is involved in the creation of various types of pesticides, like herbicides and insecticides. The action mechanism of 4-Mercaptophenylboronic acid is not entirely known. However, it is postulated that its boronic acid group can form a complex with a variety of molecules, such as carbohydrates, proteins, and nucleic acids. This complex formation can lead to the inhibition of enzyme activity, protein-protein interactions, and DNA replication. Additionally, 4-Mercaptophenylboronic acid can also form complexes with metal ions like iron and copper, potentially inhibiting metal-catalyzed reactions.


4-Mercaptophenylboronic acid (CAS 237429-33-3) References

  1. 4-Mercaptophenylboronic acid SAMs on gold: comparison with SAMs derived from thiophenol, 4-mercaptophenol, and 4-mercaptobenzoic acid.  |  Barriet, D., et al. 2007. Langmuir. 23: 8866-75. PMID: 17636994
  2. Facile synthesis of 4-mercaptophenylboronic acid functionalized gold nanoparticles for selective enrichment of glycopeptides.  |  Yao, G., et al. 2009. Rapid Commun Mass Spectrom. 23: 3493-500. PMID: 19844974
  3. 4-Mercaptophenylboronic acid: conformation, FT-IR, Raman, OH stretching and theoretical studies.  |  Parlak, C., et al. 2015. Spectrochim Acta A Mol Biomol Spectrosc. 144: 131-8. PMID: 25754388
  4. 4-Mercaptophenylboronic acid functionalized graphene oxide composites: Preparation, characterization and selective enrichment of glycopeptides.  |  Jiang, B., et al. 2016. Anal Chim Acta. 912: 41-8. PMID: 26920771
  5. 4-mercaptophenylboronic acid functionalized gold nanoparticles for colorimetric sialic acid detection.  |  Sankoh, S., et al. 2016. Biosens Bioelectron. 85: 743-750. PMID: 27266659
  6. Rapid concentration detection and differentiation of bacteria in skimmed milk using surface enhanced Raman scattering mapping on 4-mercaptophenylboronic acid functionalized silver dendrites.  |  Wang, P., et al. 2017. Anal Bioanal Chem. 409: 2229-2238. PMID: 28091716
  7. Surface-enhanced Raman spectroscopy study on the structure changes of 4-Mercaptophenylboronic Acid under different pH conditions.  |  Su, H., et al. 2017. Spectrochim Acta A Mol Biomol Spectrosc. 185: 336-342. PMID: 28599237
  8. One-step functionalization of magnetic nanoparticles with 4-mercaptophenylboronic acid for a highly efficient analysis of N-glycopeptides.  |  Yao, J., et al. 2017. Nanoscale. 9: 16024-16029. PMID: 29026904
  9. Sandwich-type biosensor for the detection of α2,3-sialylated glycans based on fullerene-palladium-platinum alloy and 4-mercaptophenylboronic acid nanoparticle hybrids coupled with Au-methylene blue-MAL signal amplification.  |  Yuan, Q., et al. 2018. Biosens Bioelectron. 102: 321-327. PMID: 29161664
  10. 4-Mercaptophenylboronic acid-modified spirally-curved mesoporous silica nanofibers coupled with ultra performance liquid chromatography-mass spectrometry for determination of brassinosteroids in plants.  |  Chen, M., et al. 2018. Food Chem. 263: 51-58. PMID: 29784327
  11. Glucose Detection of 4-Mercaptophenylboronic Acid-Immobilized Gold-Silver Core-Shell Assembled Silica Nanostructure by Surface Enhanced Raman Scattering.  |  Pham, XH., et al. 2021. Nanomaterials (Basel). 11: PMID: 33917868
  12. Immobilized Antibodies on Mercaptophenylboronic Acid Monolayers for Dual-Strategy Detection of 20S Proteasome.  |  Barsan, MM., et al. 2021. Sensors (Basel). 21: PMID: 33921330
  13. [Preparation of 4-mercaptophenylboronic acid functionalized two-dimensional molybdenum disulfide nanocomposite and its specific enrichment for N-glycopeptide].  |  Zhang, H., et al. 2020. Se Pu. 38: 891-899. PMID: 34213180
  14. Magnetic SERS Strip Based on 4-mercaptophenylboronic Acid-Modified Fe3O4@Au for Active Capture and Simultaneous Detection of Respiratory Bacteria.  |  Li, J., et al. 2023. Biosensors (Basel). 13: PMID: 36831976
  15. Colorimetric Sensing of Gram-Negative and Gram-Positive Bacteria Using 4-Mercaptophenylboronic Acid-Functionalized Gold Nanoparticles in the Presence of Polyethylene Glycol.  |  Amornwairat, P. and Pissuwan, D. 2023. ACS Omega. 8: 13456-13464. PMID: 37065017

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Mercaptophenylboronic acid, 1 g

sc-254692
1 g
$115.00