Molecular structure of 4-Mercaptophenylacetic Acid, CAS Number: 39161-84-7
4-Mercaptophenylacetic Acid (CAS 39161-84-7)
Application:
4-Mercaptophenylacetic Acid is a redox buffer that increases the folding rate of disulfide-containing proteins
CAS Number:
39161-84-7
Purity:
97%
Molecular Weight:
168.21
Molecular Formula:
C8H8O2S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Mercaptophenylacetic acid (4-MPA) is a derivative of phenylacetic acid, which is an important intermediate in the synthesis of many compounds. Additionally, 4-Mercaptophenylacetic acid is used in studies of enzyme inhibition, protein and enzyme purification, and protein-protein interactions. Moreover, it serves as a redox buffer that increases the folding rate of disulfide-containing proteins relative to traditional buffers such as glutathione and glutathione-disulfide. Also, it is used in the synthesis of fluorescent probes. Furthermore, 4-Mercaptophenylacetic acid possesses anti-inflammatory and anti-oxidant properties, and it has been reported to inhibit the activity of enzymes like proteases and phosphatases, as well as proteins such as cytochrome P450.
4-Mercaptophenylacetic Acid (CAS 39161-84-7) References
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- Application of a novel thioesterification reaction to the synthesis of chemokine CCL27 by the modified thioester method. | Hojo, H., et al. 2008. Org Biomol Chem. 6: 1808-13. PMID: 18452017
- Native chemical ligation at Asx-Cys, Glx-Cys: chemical synthesis and high-resolution X-ray structure of ShK toxin by racemic protein crystallography. | Dang, B., et al. 2013. J Am Chem Soc. 135: 11911-9. PMID: 23919482
- Imidazole-Aided Native Chemical Ligation: Imidazole as a One-Pot Desulfurization-Amenable Non-Thiol-Type Alternative to 4-Mercaptophenylacetic Acid. | Sakamoto, K., et al. 2016. Chemistry. 22: 17940-17944. PMID: 27709754
- Photopolymerized dynamic hydrogels with tunable viscoelastic properties through thioester exchange. | Brown, TE., et al. 2018. Biomaterials. 178: 496-503. PMID: 29653871
- Manipulation of Glutathione-Mediated Degradation of Thiol-Maleimide Conjugates. | Wu, H., et al. 2018. Bioconjug Chem. 29: 3595-3605. PMID: 30285419
- Triple Function of 4-Mercaptophenylacetic Acid Promotes One-Pot Multiple Peptide Ligation. | Kamo, N., et al. 2018. Angew Chem Int Ed Engl. 57: 16533-16537. PMID: 30346110
- Corrigendum: Triple Function of 4-Mercaptophenylacetic Acid Promotes One-Pot Multiple Peptide Ligation. | Kamo, N., et al. 2019. Angew Chem Int Ed Engl. 58: 1540. PMID: 30694014
- Utilizing Molecular Hyperpolarizability for Trace Analysis: A Surface-Enhanced Hyper-Raman Scattering Study of Uranyl Ion. | Trujillo, MJ. and Camden, JP. 2018. ACS Omega. 3: 6660-6664. PMID: 31458840
- Dually Reactive Long Recombinant Linkers for Bioconjugations as an Alternative to PEG. | Kjeldsen, T., et al. 2020. ACS Omega. 5: 19827-19833. PMID: 32803078
- A new electrochemical impedance biosensor based on aromatic thiol for alpha-1 antitrypsin determination. | YaĞar, H., et al. 2021. Turk J Chem. 45: 104-118. PMID: 33679157
- Development of a functional impedimetric immunosensor for accurate detection of thyroid-stimulating hormone. | Asav, E. 2021. Turk J Chem. 45: 819-834. PMID: 34385869
- Thiol Catalysis of Selenosulfide Bond Cleavage by a Triarylphosphine. | Firstova, O., et al. 2022. J Org Chem. 87: 9426-9430. PMID: 35763672
- Electrostatic Assistance of 4-Mercaptophenylacetic Acid-Catalyzed Native Chemical Ligation. | Ollivier, N., et al. 2023. Org Lett. 25: 2696-2700. PMID: 37027311
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Mercaptophenylacetic Acid, 1 g | sc-206903 | 1 g | $158.00 |