Date published: 2026-4-27

1-800-457-3801

SCBT Portrait Logo
Seach Input

4-Iodopyrimidine (CAS 31462-57-4)

0.0(0)
Write a reviewAsk a question

CAS Number:
31462-57-4
Molecular Weight:
205.98
Molecular Formula:
C4H3IN2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

4-Iodopyrimidine holds significant value in scientific research, finding extensive applications across various domains. It is particularly employed in the synthesis of pharmaceuticals, agrochemicals, and materials science. Furthermore, it plays a role in the advancement of innovative materials, including OLEDs and conducting polymers. In terms of its mechanism of action, 4-Iodopyrimidine is believed to act as a DNA intercalator, inducing DNA damage that ultimately leads to cell death. Additionally, it has demonstrated the ability to inhibit the activity of various enzymes, such as topoisomerase and histone deacetylase, which play pivotal roles in DNA replication and gene expression.


4-Iodopyrimidine (CAS 31462-57-4) References

  1. Synthesis of 14-azacamptothecin, a water-soluble topoisomerase I poison.  |  Rahier, NJ., et al. 2005. Org Lett. 7: 835-7. PMID: 15727453
  2. Pyrazolopyridine antiherpetics: SAR of C2' and C7 amine substituents.  |  Johns, BA., et al. 2005. Bioorg Med Chem. 13: 2397-411. PMID: 15755642
  3. Lithium-mediated zincation of pyrazine, pyridazine, pyrimidine, and quinoxaline.  |  Seggio, A., et al. 2007. J Org Chem. 72: 6602-5. PMID: 17655361
  4. Deprotonative metalation of functionalized aromatics using mixed lithium-cadmium, lithium-indium, and lithium-zinc species.  |  Snégaroff, K., et al. 2009. Chemistry. 15: 10280-90. PMID: 19688794
  5. A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice.  |  Leng, L., et al. 2011. J Immunol. 186: 527-38. PMID: 21106847
  6. Recent advances in the studies on luotonins.  |  Liang, JL., et al. 2011. Molecules. 16: 4861-83. PMID: 21677601
  7. Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides.  |  René, O., et al. 2014. Org Lett. 16: 3468-71. PMID: 24937120
  8. Catalytic Three-Component Machinery: Control of Catalytic Activity by Machine Speed.  |  Paul, I., et al. 2018. Angew Chem Int Ed Engl. 57: 354-358. PMID: 29166556
  9. Palladium-Catalyzed Cross-Coupling Reactions: A Powerful Tool for the Synthesis of Agrochemicals.  |  Devendar, P., et al. 2018. J Agric Food Chem. 66: 8914-8934. PMID: 30060657
  10. Discovery of first-in-class imidazothiazole-based potent and selective ErbB4 (HER4) kinase inhibitors.  |  Zaraei, SO., et al. 2021. Eur J Med Chem. 224: 113674. PMID: 34237622
  11. Indole Inhibitors of MMP-13 for Arthritic Disorders.  |  Taylor, SJ., et al. 2021. ACS Omega. 6: 18635-18650. PMID: 34337203
  12. 4-Iodopyrimidine Labeling Reveals Nuclear Translocation and Nuclease Activity for Both MIF and MIF2.  |  Xiao, Z., et al. 2022. Chemistry. 28: e202103030. PMID: 34724273
  13. Exploiting Coordination Effects for the Regioselective Zincation of Diazines Using TMPZnX⋅LiX (X=Cl, Br).  |  Kremsmair, A., et al. 2022. Angew Chem Int Ed Engl. 61: e202210491. PMID: 35943036

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Iodopyrimidine, 500 mg

sc-488501
500 mg
$388.00