Date published: 2025-10-16

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4-Hydroxythiobenzamide (CAS 25984-63-8)

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CAS Number:
25984-63-8
Molecular Weight:
153.2
Molecular Formula:
C7H7NOS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Hydroxythiobenzamide is utilized in organic chemistry, focused on the synthesis and study of sulfur-containing compounds. Its role as a building block in the synthesis of various heterocyclic compounds is critical, particularly for creating molecules that mimic biologically active structures. In catalysis studies, 4-Hydroxythiobenzamide is investigated for its potential as a ligand in catalytic systems, which are used to facilitate reactions involving the formation or breaking of chemical bonds. 4-Hydroxythiobenzamide is also employed in the study of enzyme inhibition. 4-Hydroxythiobenzamide is applied in materials science to develop polymers with specific optical properties, leveraging its ability to absorb light within certain wavelengths.


4-Hydroxythiobenzamide (CAS 25984-63-8) References

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  2. Vibrational spectra, NBO, HOMO-LUMO and conformational stability studies of 4-hydroxythiobenzamide.  |  Sambathkumar, K. 2015. Spectrochim Acta A Mol Biomol Spectrosc. 147: 51-66. PMID: 25827766
  3. Synthesis and Pharmacological Evaluation of Novel Adenine-Hydrogen Sulfide Slow Release Hybrids Designed as Multitarget Cardioprotective Agents.  |  Lougiakis, N., et al. 2016. J Med Chem. 59: 1776-90. PMID: 26809888
  4. Long-term release of a thiobenzamide from a backbone functionalized poly(lactic acid).  |  Long, TR., et al. 2015. Polym Chem. 6: 7188-7195. PMID: 26870159
  5. Profound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APCMin/+ Mouse Model of Intestinal Tumorigenesis.  |  Paul-Clark, M., et al. 2016. PLoS One. 11: e0147289. PMID: 26910063
  6. Effect of Ketoprofen and ATB-352 on the Immature Human Intestine: Identification of Responders and Non-responders.  |  Thibault, MP., et al. 2019. J Pediatr Gastroenterol Nutr. 68: 623-629. PMID: 31022092
  7. Hydrogen sulfide and dermatological diseases.  |  Coavoy-Sánchez, SA., et al. 2020. Br J Pharmacol. 177: 857-865. PMID: 31051046
  8. Sustained Release of Hydrogen Sulfide (H2S) from Poly(Lactic Acid) Functionalized 4-Hydroxythiobenzamide Microparticles to Protect Against Oxidative Damage.  |  Do, AV., et al. 2019. Ann Biomed Eng. 47: 1691-1700. PMID: 31139973
  9. Toxicities and beneficial protection of H2S donors based on nonsteroidal anti-inflammatory drugs.  |  Zhang, J., et al. 2019. Medchemcomm. 10: 742-756. PMID: 31191865
  10. Synthesis of Chimeric Thiazolo-Nootkatone Derivatives as Potent Antimicrobial Agents.  |  Alkhaibari, IS., et al. 2021. ChemMedChem. 16: 2628-2637. PMID: 33955181
  11. Hydrogen Sulfide in Skin Diseases: A Novel Mediator and Therapeutic Target.  |  Xiao, Q., et al. 2021. Oxid Med Cell Longev. 2021: 6652086. PMID: 33986916
  12. Novel Hydrogen Sulfide (H2S)-Releasing BW-HS-101 and Its Non-H2S Releasing Derivative in Modulation of Microscopic and Molecular Parameters of Gastric Mucosal Barrier.  |  Bakalarz, D., et al. 2021. Int J Mol Sci. 22: PMID: 34069086
  13. Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis.  |  Zhang, X., et al. 2023. Antioxidants (Basel). 12: PMID: 37237928

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Hydroxythiobenzamide, 1 g

sc-284257
1 g
$66.00

4-Hydroxythiobenzamide, 5 g

sc-284257A
5 g
$204.00