Molecular structure of 4-Hydroxyphenylretinamide, CAS Number: 65646-68-6
4-Hydroxyphenylretinamide (CAS 65646-68-6)
Alternate Names:
Retinoic acid p-hydroxyanilide; Fenretinide; 4-HPR
Application:
4-Hydroxyphenylretinamide is an agonist displaying activity at retinoid receptors
CAS Number:
65646-68-6
Molecular Weight:
391.55
Molecular Formula:
C26H33NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Hydroxyphenylretinamide (Fenretinide) is a synthetic retinoid analog of all trans retinoic acid, which displays antiproliferative effects on cultured human breast cancer cells. In addition, 4-Hydroxyphenylretinamide functions as a selective activator of RAR (retinoid receptors). Studies involving lymphoid and myeloid malignant cell lines indicate that 4-Hydroxyphenylretinamide can induce apoptosis and reduce cell growth. These studies suggest that 4-Hydroxyphenylretinamide and all trans retanoic acid may bind to two different receptors to induce apoptosis.
4-Hydroxyphenylretinamide (CAS 65646-68-6) References
- Retinoic acid and 4-hydroxyphenylretinamide induce growth inhibition and tissue transglutaminase through different signal transduction pathways in mouse fibroblasts (NIH 3T3 cells). | Giandomenico, V., et al. 1999. Carcinogenesis. 20: 1133-5. PMID: 10357800
- Synthesis and biological activity of glycosyl conjugates of N-(4-hydroxyphenyl)retinamide. | Winum, JY., et al. 2001. Farmaco. 56: 319-24. PMID: 11421261
- Effect of 4-hydroxyphenylretinamide on human cervical epithelial and cancer cell lines. | Zou, C., et al. 2003. J Soc Gynecol Investig. 10: 41-8. PMID: 12517593
- Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide. | Wang, Y., et al. 2006. Mol Cancer Ther. 5: 1060-72. PMID: 16648578
- Retinoids induce tissue transglutaminase in NIH-3T3 cells. | Cai, D., et al. 1991. Biochem Biophys Res Commun. 175: 1119-24. PMID: 1673838
- 4-Hydroxyphenylretinamide (4HPR) derivatives regulate aromatase activity and expression in breast cancer cells. | Su, B., et al. 2008. J Steroid Biochem Mol Biol. 109: 40-6. PMID: 18248980
- Effect of retinyl acetate and 4-hydroxyphenylretinamide on initiation of chemically-induced mammary tumors. | Grubbs, CJ., et al. 1990. Anticancer Res. 10: 661-6. PMID: 2142393
- Effect of 4-hydroxyphenylretinamide and retinoic acid on proliferation and cell cycle of cultured human breast cancer cells. | Marth, C., et al. 1985. J Natl Cancer Inst. 75: 871-5. PMID: 2932587
- Differential effects of N-(4-hydroxyphenyl)retinamide and retinoic acid on neuroblastoma cells: apoptosis versus differentiation. | Ponzoni, M., et al. 1995. Cancer Res. 55: 853-61. PMID: 7850799
- N-(4-hydroxyphenyl)retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid. | Delia, D., et al. 1993. Cancer Res. 53: 6036-41. PMID: 8261419
- 4-Hydroxyphenyl retinamide is a highly selective activator of retinoid receptors. | Fanjul, AN., et al. 1996. J Biol Chem. 271: 22441-6. PMID: 8798408
- Combined effect of tamoxifen or interferon-beta and 4-hydroxyphenylretinamide on the growth of breast cancer cell lines. | Coradini, D., et al. 1997. Tumour Biol. 18: 22-9. PMID: 8989922
- Effect of early vs. late administration of 4-hydroxyphenylretinamide (4-HPR) on N-methyl-N-nitrosourea (MNU)-induced mammary tumorigenesis. | Crist, KA., et al. 1997. J Cell Biochem Suppl. 27: 92-9. PMID: 9591198
Inhibitor of:
1300002K09Rik, Angiogenesis, brain and placenta PFK-2, CDS1, Ceramide Kinase, Ceramide Synthase (CERS; LASS), COUP-TF2, CRBP I, CRBP II, CYP26A1, Cytokeratin 5, DHRS2, DHRS3, DHRS4L2, DHRS7B, DPY19L1, EG436008, ETFDH, FAM126B, HoxB1, IRBP, LASS1, LASS2, LCE2A, Lipocalin-8, Lipocalin-L1, Lipophilin B, LOC402377, LRAT, N-SMase, NCYM, NRIP2, Nup210L, OPN1MW, Paralemmin 3, Prohibitin 2, Rarres1, RBP2, RDH12, RDH2, RDH7, RETSAT, RGR, RPE, SMS2, SOD-2, SPDL-1, SPTLC1, Stra6, TIG2, TMEM12, TMEM25, Usherin, VAP-B/C, and ZDHHC.Activator of:
AUP1, Baculovirus gp64, CRABP-I, CRABP-II, CRBP III, CRBP IV, CtBP1, CYP26C1, DHRS7C, DHRS9, DnaJC3, Flavivirus, IRE1α, LASS3, NP60, OSBP2, PIG-K, PPT2, PSAPL1, PTAG, RAI3, RAR, RARα1, RARα2, Rarres1, RDH8, Retinal RX, Retinal RX2, RORβ, TIG1, TIG3, TSPY, and UGCG.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Hydroxyphenylretinamide, 5 mg | sc-200900 | 5 mg | $104.00 | |||
4-Hydroxyphenylretinamide, 25 mg | sc-200900A | 25 mg | $315.00 |