Molecular structure of 4-Hydroxyphenylacetic acid, CAS Number: 156-38-7
4-Hydroxyphenylacetic acid (CAS 156-38-7)
See product citations (2)
Alternate Names:
p-hydroxyphenylacetic acid
CAS Number:
156-38-7
Purity:
≥98%
Molecular Weight:
152.15
Molecular Formula:
C8H8O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
4-Hydroxyphenylacetic acid (4-HPAA) is a naturally occurring compound present in various organisms, including plants, animals, and humans. This essential metabolite arises from the breakdown of the neurotransmitters dopamine and norepinephrine. Further, 4-Hydroxyphenylacetic acid is a reagent used in the acylation of phenols and amines. Although the precise mechanism of action of 4-Hydroxyphenylacetic acid remains incompletely elucidated, ongoing studies suggest that it exerts its effects through the modulation of catecholamine neurotransmitter systems.
4-Hydroxyphenylacetic acid (CAS 156-38-7) References
- The presence of 4-hydroxyphenylacetic acid in human saliva and the possibility of its nitration by salivary nitrite in the stomach. | Takahama, U., et al. 2002. FEBS Lett. 518: 116-8. PMID: 11997029
- Nitration of the salivary component 4-hydroxyphenylacetic acid in the human oral cavity: enhancement of nitration under acidic conditions. | Takahama, U., et al. 2009. Eur J Oral Sci. 117: 555-62. PMID: 19758252
- 4-hydroxyphenylacetic acid attenuated inflammation and edema via suppressing HIF-1α in seawater aspiration-induced lung injury in rats. | Liu, Z., et al. 2014. Int J Mol Sci. 15: 12861-84. PMID: 25050781
- Design and Construction of a Whole Cell Bacterial 4-Hydroxyphenylacetic Acid and 2-Phenylacetic Acid Bioassay. | Dierckx, S., et al. 2015. Front Bioeng Biotechnol. 3: 88. PMID: 26137458
- 4-Hydroxyphenylacetic acid oxidation in sulfate and real olive oil mill wastewater by electrochemical advanced processes with a boron-doped diamond anode. | Flores, N., et al. 2017. J Hazard Mater. 321: 566-575. PMID: 27694020
- Pharmacokinetics of dietary kaempferol and its metabolite 4-hydroxyphenylacetic acid in rats. | Zabela, V., et al. 2016. Fitoterapia. 115: 189-197. PMID: 27810397
- 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice. | Zhao, H., et al. 2018. Front Pharmacol. 9: 653. PMID: 29973881
- Combining directed evolution of pathway enzymes and dynamic pathway regulation using a quorum-sensing circuit to improve the production of 4-hydroxyphenylacetic acid in Escherichia coli. | Shen, YP., et al. 2019. Biotechnol Biofuels. 12: 94. PMID: 31044007
- Resveratrol reduces obesity in high-fat diet-fed mice via modulating the composition and metabolic function of the gut microbiota. | Wang, P., et al. 2020. Free Radic Biol Med. 156: 83-98. PMID: 32305646
- Microbiota metabolites modulate the T helper 17 to regulatory T cell (Th17/Treg) imbalance promoting resilience to stress-induced anxiety- and depressive-like behaviors. | Westfall, S., et al. 2021. Brain Behav Immun. 91: 350-368. PMID: 33096252
- ATP and NADPH engineering of Escherichia coli to improve the production of 4-hydroxyphenylacetic acid using CRISPRi. | Shen, YP., et al. 2021. Biotechnol Biofuels. 14: 100. PMID: 33879249
- Antimicrobial mechanism of 4-hydroxyphenylacetic acid on Listeria monocytogenes membrane and virulence. | YujiaLiu, ., et al. 2021. Biochem Biophys Res Commun. 572: 145-150. PMID: 34364294
- Ethanol extract of Sargarsum fusiforme alleviates HFD/STZ-induced hyperglycemia in association with modulation of gut microbiota and intestinal metabolites in type 2 diabetic mice. | Wu, S., et al. 2021. Food Res Int. 147: 110550. PMID: 34399527
- Biosensor-assisted evolution for high-level production of 4-hydroxyphenylacetic acid in Escherichia coli. | Shen, YP., et al. 2022. Metab Eng. 70: 1-11. PMID: 34965469
- Sulfation of Phenolic Acids: Chemoenzymatic vs. Chemical Synthesis. | Kolaříková, V., et al. 2022. Int J Mol Sci. 23: PMID: 36499496
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Hydroxyphenylacetic acid, 5 g | sc-206897 | 5 g | $33.00 | |||
4-Hydroxyphenylacetic acid, 25 g | sc-206897A | 25 g | $55.00 |