(4-Hydroxymethyl-2-pyridin-3-yl-oxazolidin-4-yl)-methanol (CAS 312620-99-8)
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9Z,11E,13E-Octadecatrienoic Acid ethyl ester is a conjugated polyunsaturated fatty acid found in plant seed oil which accounts for about 70% in tung oil and 60% of the total fatty acid composition of bitter gourd seed oil. alpha-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, alpha-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARgamma. In DLD-1 cells supplemented with alpha-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 µM. It also inhibits DNA polymerases and Topo (topoisomerases) with IC50s ranging from ~5-20 muM for different isoforms of the enzymes. alpha-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(4-Hydroxymethyl-2-pyridin-3-yl-oxazolidin-4-yl)-methanol, 500 mg | sc-316544 | 500 mg | $255.00 |