Molecular structure of 4-Hydroxyisoleucine, CAS Number: 781658-23-9
4-Hydroxyisoleucine (CAS 781658-23-9)
Alternate Names:
2-Amino-2,3,5-trideoxy-3-methyl-D-xylonic Acid; (2S,3R,4S)-4-Hydroxyisoleucine Major Isomer and (2R,3R,4S)-4-Hydroxyisoleucine Minor Isomer
Application:
4-Hydroxyisoleucine is an amino acid used in the research of treatments for type II diabetes
CAS Number:
781658-23-9
Molecular Weight:
147.13
Molecular Formula:
C6H13NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Hydroxyisoleucine is a compound that functions as a regulator of glucose metabolism. It acts by stimulating insulin secretion from pancreatic beta cells and increasing insulin sensitivity in peripheral tissues. 4-Hydroxyisoleucine also plays a role in the activation of the enzyme glycogen synthase, which promotes the storage of glucose as glycogen in the liver and muscles. 4-Hydroxyisoleucine may inhibit gluconeogenesis, the process by which the liver produces glucose from non-carbohydrate sources. At the molecular level, 4-Hydroxyisoleucine interacts with specific receptors and signaling pathways involved in glucose homeostasis, ultimately leading to improved glucose uptake and utilization by cells.
4-Hydroxyisoleucine (CAS 781658-23-9) References
- High production of 4-hydroxyisoleucine in Corynebacterium glutamicum by multistep metabolic engineering. | Zhang, C., et al. 2018. Metab Eng. 49: 287-298. PMID: 30223026
- Optimization of ribosomal binding site sequences for gene expression and 4-hydroxyisoleucine biosynthesis in recombinant corynebacterium glutamicum. | Shi, F., et al. 2020. Enzyme Microb Technol. 140: 109622. PMID: 32912682
- 4-Hydroxyisoleucine relieves inflammation through iRhom2-dependent pathway in co-cultured macrophages and adipocytes with LPS stimulation. | Zhou, C., et al. 2020. BMC Complement Med Ther. 20: 373. PMID: 33298044
- 4-Hydroxyisoleucine Alleviates Macrophage-Related Chronic Inflammation and Metabolic Syndrome in Mice Fed a High-Fat Diet. | Yang, J., et al. 2020. Front Pharmacol. 11: 606514. PMID: 33551809
- A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats. | Wadhwa, G., et al. 2022. Biomed Chromatogr. 36: e5275. PMID: 34738247
- Neuroprotective efficacy of 4-Hydroxyisoleucine in experimentally induced intracerebral hemorrhage. | Mehmood Siddiqui, E., et al. 2021. Saudi J Biol Sci. 28: 6417-6431. PMID: 34764759
- Sustainable production of 4-hydroxyisoleucine with minimised carbon loss by simultaneously utilising glucose and xylose in engineered Escherichia coli. | Wei, M., et al. 2022. Bioresour Technol. 354: 127196. PMID: 35460845
- Activation of IGF-1/GLP-1 Signalling via 4-Hydroxyisoleucine Prevents Motor Neuron Impairments in Experimental ALS-Rats Exposed to Methylmercury-Induced Neurotoxicity. | Shandilya, A., et al. 2022. Molecules. 27: PMID: 35745001
- 4-hydroxyisoleucine mediated IGF-1/GLP-1 signalling activation prevents propionic acid-induced autism-like behavioural phenotypes and neurochemical defects in experimental rats. | Bhalla, S. and Mehan, S. 2022. Neuropeptides. 96: 102296. PMID: 36307249
- 4-Hydroxyisoleucine inhibits tumor growth by triggering endoplasmic reticulum stress and autophagy. | Li, P., et al. 2022. Curr Res Pharmacol Drug Discov. 3: 100127. PMID: 36568272
- Computational pharmacology and computational chemistry of 4-hydroxyisoleucine: Physicochemical, pharmacokinetic, and DFT-based approaches. | Ahmad, I., et al. 2023. Front Chem. 11: 1145974. PMID: 37123881
- Quorum sensing-mediated dynamic regulation of 4-hydroxyisoleucine biosynthesis in Corynebacterium glutamicum. | Ma, F., et al. 2023. World J Microbiol Biotechnol. 39: 181. PMID: 37142865
- Exploring L-isoleucine riboswitches for enhancing 4-hydroxyisoleucine production in Corynebacterium glutamicum. | Xiang, Y., et al. 2023. Biotechnol Lett.. PMID: 37395871
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Radixin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Hydroxyisoleucine, 10 mg | sc-210087 | 10 mg | $173.00 |