Date published: 2026-4-5

1-800-457-3801

SCBT Portrait Logo
Seach Input

4-Hydroxyindole (CAS 2380-94-1)

0.0(0)
Write a reviewAsk a question

Application:
4-Hydroxyindole is a pindolol impurity
CAS Number:
2380-94-1
Purity:
≥98%
Molecular Weight:
133.15
Molecular Formula:
C8H7NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

4-Hydroxyindole (4-HI) is an aromatic heterocyclic compound that garners significant attention in scientific research and laboratory experiments. This naturally occurring compound is found abundantly in plants, fungi, and animals and serves as a component in the production of various industrial products. While the precise mechanism of action of 4-Hydroxyindole remains under investigation, it is believed to exert its effects by inhibiting specific enzymes, including cytochrome P450 and monoamine oxidase.


4-Hydroxyindole (CAS 2380-94-1) References

  1. Conversion of 1-benzoylindole by Aspergillus strains.  |  Sukhodolskaya, GV., et al. 2000. Appl Microbiol Biotechnol. 53: 695-700. PMID: 10919329
  2. Rational design of an indolebutanoic acid derivative as a novel aldose reductase inhibitor based on docking and 3D QSAR studies of phenethylamine derivatives.  |  Sun, WS., et al. 2003. J Med Chem. 46: 5619-27. PMID: 14667216
  3. Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives.  |  Cohen, T., et al. 2006. Biochemistry. 45: 4727-35. PMID: 16605241
  4. Synthesis and biological evaluation of novel angular fused Pyrrolocoumarins.  |  Kontogiorgis, C., et al. 2008. J Enzyme Inhib Med Chem. 23: 43-9. PMID: 18341252
  5. Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.  |  Manevski, N., et al. 2010. Drug Metab Dispos. 38: 386-95. PMID: 20007669
  6. Bicyclic compounds repress membrane vesicle production and Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa.  |  Tashiro, Y., et al. 2010. FEMS Microbiol Lett. 304: 123-30. PMID: 20146747
  7. In vitro assay of six UDP-glucuronosyltransferase isoforms in human liver microsomes, using cocktails of probe substrates and liquid chromatography-tandem mass spectrometry.  |  Seo, KA., et al. 2014. Drug Metab Dispos. 42: 1803-10. PMID: 25122565
  8. Biocatalytic Production of Psilocybin and Derivatives in Tryptophan Synthase-Enhanced Reactions.  |  Blei, F., et al. 2018. Chemistry. 24: 10028-10031. PMID: 29750381
  9. Biofilm Formation by Streptococcus mutans is Enhanced by Indole via the Quorum Sensing Pathway.  |  Inaba, T., et al. 2020. Microbes Environ. 35: PMID: 32350164
  10. Synthetic studies toward inducamide C.  |  Nabi, AA., et al. 2021. Org Biomol Chem. 19: 416-420. PMID: 33313627
  11. Development and validation of an LC-MS/MS method for the bioanalysis of psilocybin's main metabolites, psilocin and 4-hydroxyindole-3-acetic acid, in human plasma.  |  Kolaczynska, KE., et al. 2021. J Chromatogr B Analyt Technol Biomed Life Sci. 1164: 122486. PMID: 33485158
  12. Fluorescent Pyranoindole Congeners: Synthesis and Photophysical Properties of Pyrano[3,2-f], [2,3-g], [2,3-f], and [2,3-e]Indoles.  |  Sharapov, AD., et al. 2022. Molecules. 27: PMID: 36557999
  13. Psammopemmins (A-C), Novel Brominated 4-Hydroxyindole Alkaloids From an Antarctic Sponge, Psammopemma sp.  |  MS Butler, RJ Capon and CC Lu. 1871 - 1877. Australian Journal of Chemistry. 45(11): 1871 - 1877.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Hydroxyindole, 1 g

sc-216890
1 g
$215.00