4-Hydroxycinnamic acid (CAS 7400-08-0)
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Alternate Names:
p-Coumaric acid; trans-4-Hydroxycinnamic acid
CAS Number:
7400-08-0
Molecular Weight:
164.16
Molecular Formula:
C9H8O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Hydroxycinnamic acid, known as p-coumaric acid, is a naturally occurring compound found abundantly in various plants. As a phenolic acid, it possesses an aromatic ring structure with a hydroxyl group attached. This organic compound serves as a vital intermediate in the synthesis of lignin, a fundamental component of wood, and can also be found in the cell walls of numerous fruits and vegetables. In vitro investigations this compound is used to explore its effects on cell proliferation, apoptosis, and cell cycle regulation. Although the precise mechanism of action of 4-Hydroxycinnamic acid remains incompletely understood, current understanding suggests that it functions by scavenging free radicals.
4-Hydroxycinnamic acid (CAS 7400-08-0) References
- Towards the synthesis of aryl glucuronides as potential heparanase probes. An interesting outcome in the glycosidation of glucuronic acid with 4-hydroxycinnamic acid. | Pearson, AG., et al. 2005. Carbohydr Res. 340: 2077-85. PMID: 16054610
- Purification and reconstitution of PYP-phytochrome with biliverdin and 4-hydroxycinnamic acid. | Chung, YH., et al. 2007. Methods Enzymol. 422: 184-9. PMID: 17628140
- Physicochemical characteristics, hydroxycinnamic acids (ferulic acid, P-coumaric acid) and their ratio, and in situ biodegradability: comparison of genotypic differences among six barley varieties. | Du, L., et al. 2009. J Agric Food Chem. 57: 4777-83. PMID: 19432476
- Production of 4-ethylphenol from 4-hydroxycinnamic acid by Lactobacillus sp. isolated from a swine waste lagoon. | Kridelbaugh, D., et al. 2010. J Appl Microbiol. 109: 190-8. PMID: 20028439
- Biotransformation of p-coumaric acid and 2,4-dichlorophenoxy acetic acid by Azotobacter sp. strain SSB81. | Gauri, SS., et al. 2012. Bioresour Technol. 126: 350-3. PMID: 23127838
- p-Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities. | Pei, K., et al. 2016. J Sci Food Agric. 96: 2952-62. PMID: 26692250
- 4-Hydroxycinnamic acid suppresses airway inflammation and mucus hypersecretion in allergic asthma induced by ovalbumin challenge. | Ko, JW., et al. 2020. Phytother Res. 34: 624-633. PMID: 31724257
- Understanding the combined effect and inhibition mechanism of 4-hydroxycinnamic acid and ferulic acid as tyrosinase inhibitors. | Yu, Q. and Fan, L. 2021. Food Chem. 352: 129369. PMID: 33706137
- Aspergillus niger uses the peroxisomal CoA-dependent β-oxidative genes to degrade the hydroxycinnamic acids caffeic acid, ferulic acid, and p-coumaric acid. | Lubbers, RJM., et al. 2021. Appl Microbiol Biotechnol. 105: 4199-4211. PMID: 33950281
- Evaluation of bacterial hosts for conversion of lignin-derived p-coumaric acid to 4-vinylphenol. | Rodriguez, A., et al. 2021. Microb Cell Fact. 20: 181. PMID: 34526022
- An UHPLC/LC-MS illustrated the dynamic profiling of balanophorin B, gallic acid, and 4-hydroxycinnamic acid in rat as 3 molecular entities from Balanophora simaoensis. | Xu, X., et al. 2022. J Chromatogr B Analyt Technol Biomed Life Sci. 1190: 123103. PMID: 35021136
- P-Coumaric Acid Reverses Depression-Like Behavior and Memory Deficit Via Inhibiting AGE-RAGE-Mediated Neuroinflammation. | Yu, XD., et al. 2022. Cells. 11: PMID: 35626632
- Polyphenol oxidase inhibited by 4-hydroxycinnamic acid and naringenin: Multi-spectroscopic analyses and molecular docking simulation at different pH. | Jiang, H., et al. 2022. Food Chem. 396: 133662. PMID: 35839725
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CD13.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Hydroxycinnamic acid, 5 g | sc-480359 | 5 g | $15.00 |