Molecular structure of 4-Hydroxycarbazeran, CAS Number: 96724-43-5
4-Hydroxycarbazeran (CAS 96724-43-5)
Alternate Names:
1-(3,4-Dihydro-6,7-dimethoxy-4-oxo-1-phthalazinyl)-4-piperidinyl Ester Ethylcarbamic Acid
CAS Number:
96724-43-5
Molecular Weight:
376.41
Molecular Formula:
C18H24N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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4-Hydroxycarbazeran is a derivative formed during the metabolism of Carbazeran. It serves as an enzyme probe and falls under the category of hydrazine compounds. The introduction of a hydroxyl group into organic molecules like carbazeran can impact their solubility, metabolism, and interaction with biological targets. For instance, hydroxylation is a common metabolic pathway that increases the polarity of a compound, potentially enhancing its excretion from the body or altering its affinity for specific receptors or enzymes. The metabolic conversion of 4-Hydroxycarbazeran involves the enzymes aldehyde oxidase and sulfation.
4-Hydroxycarbazeran (CAS 96724-43-5) References
- Aldehyde oxidase activity in fresh human skin. | Manevski, N., et al. 2014. Drug Metab Dispos. 42: 2049-57. PMID: 25249692
- Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation. | Manevski, N., et al. 2015. Drug Metab Dispos. 43: 126-39. PMID: 25339109
- A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834. | Sodhi, JK., et al. 2015. Drug Metab Dispos. 43: 908-15. PMID: 25845827
- Molecular Cloning and Characterization of Marmoset Aldehyde Oxidase. | Uehara, S., et al. 2017. Drug Metab Dispos. 45: 883-886. PMID: 28487309
- Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS). | Yilmaz, Y., et al. 2019. Drug Metab Lett. 13: 53-63. PMID: 30345935
- Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review. | Kazem, S., et al. 2019. Drug Discov Today. 24: 1899-1910. PMID: 31176740
- In Vitro and In Silico Analyses of the Inhibition of Human Aldehyde Oxidase by Bazedoxifene, Lasofoxifene, and Structural Analogues. | Chen, S., et al. 2019. J Pharmacol Exp Ther. 371: 75-86. PMID: 31289113
- (-)-N-3-Benzylphenobarbital Is Superior to Omeprazole and (+)-N-3-Benzylnirvanol as a CYP2C19 Inhibitor in Suspended Human Hepatocytes. | Cuypers, ML., et al. 2020. Drug Metab Dispos. 48: 1121-1128. PMID: 32839278
- Oxidative metabolism of carbazeran in vitro by liver cytosol of baboon and man. | Kaye, B., et al. 1985. Xenobiotica. 15: 237-42. PMID: 4024658
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Hydroxycarbazeran, 1 mg | sc-490068 | 1 mg | $475.00 |