4-Hydroxy Valsartan (Mixture of Diastereomers) (CAS 188259-69-0)

4-Hydroxy Valsartan (Mixture of Diastereomers) represents a chemically modified form of the parent compound valsartan, distinguished by the addition of a hydroxyl group at the 4th position. This structural alteration introduces stereochemical complexity, resulting in a mixture of diastereomers that exhibit unique physicochemical properties and interactions within biological systems. The introduction of the hydroxyl group significantly impacts the compound′s solubility, binding affinity, and metabolic pathway, making it a subject of interest in pharmacokinetic and metabolic studies. The presence of different diastereomers allows researchers to explore the stereochemical influences on the compound′s biological activity, including its interaction with specific receptors or enzymes involved in the regulation of blood pressure and cardiovascular function. As a potent angiotensin II receptor (AT1R) inhibitor, 4-Hydroxy Valsartan (Mixture of Diastereomers) causes a reduction in the production of angiotensin II, resulting in lowered blood pressure. Notably, inhibiting the action of angiotensin II prevents vasoconstriction, enabling larger capillary blood volume.