4-Hydroxy Propofol (CAS 1988-10-9)
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4-Hydroxy Propofol is a metabolite of propofol, which primarily finds its application in research applications that aim to understand the metabolism and pharmacokinetics of propofol itself. Studies involving 4-Hydroxy Propofol often focus on elucidating metabolic pathways in the liver, since it is formed through the action of the enzyme CYP2B6. Research involving this compound can include the use of chromatography and mass spectrometry to quantify its presence in biological samples, which is for pharmacokinetic modeling. Additionally, 4-Hydroxy Propofol is used in in vitro studies to investigate its potential effects on cellular signaling pathways that are related to the parent compound′s mechanism of action. This research is particularly relevant in the field of biochemistry and toxicology, where understanding the metabolic fate of compounds is essential for assessing their overall impact on biological systems.
4-Hydroxy Propofol (CAS 1988-10-9) References
- Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity. | Jones, PJ., et al. 2007. J Pharmacol Exp Ther. 320: 828-36. PMID: 17090703
- An investigation of potential genetic determinants of propofol requirements and recovery from anaesthesia. | Iohom, G., et al. 2007. Eur J Anaesthesiol. 24: 912-9. PMID: 17555608
- Pharmacological actions of oximino-propofol analogues at GABA(B) autoreceptors. | Parker, DA., et al. 2011. Clin Exp Pharmacol Physiol. 38: 203-7. PMID: 21255061
- Ring-oxidative biotransformation and drug interactions of propofol in the livers of rats. | Tai, YT., et al. 2015. Biomed Res Int. 2015: 658928. PMID: 25710017
- Significance of metabolites in the environmental risk assessment of pharmaceuticals consumed by human. | Han, EJ. and Lee, DS. 2017. Sci Total Environ. 592: 600-607. PMID: 28318699
- The use of PBPK modeling across the pediatric age range using propofol as a case. | Michelet, R., et al. 2018. J Pharmacokinet Pharmacodyn. 45: 765-785. PMID: 30298439
- Propofol anesthesia increases dopamine and serotonin activities at the somatosensory cortex in rats: a microdialysis study. | Shyr, MH., et al. 1997. Anesth Analg. 84: 1344-8. PMID: 9174318
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Hydroxy Propofol, 1 mg | sc-210057 | 1 mg | $375.00 | |||
4-Hydroxy Propofol, 10 mg | sc-210057A | 10 mg | $3206.00 | |||
4-Hydroxy Propofol, 50 mg | sc-210057B | 50 mg | $16000.00 | |||
4-Hydroxy Propofol, 100 mg | sc-210057C | 100 mg | $31500.00 |