Molecular structure of 4-Hydroxy Duloxetine, CAS Number: 662149-13-5
4-Hydroxy Duloxetine (CAS 662149-13-5)
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Application:
4-Hydroxy Duloxetine is a major metabolite of Duloxetine
CAS Number:
662149-13-5
Molecular Weight:
313.41
Molecular Formula:
C18H19NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Hydroxy Duloxetine (4-HD) is a major metabolite of Duloxetine. The potential effects of 4-Hydroxy Duloxetine on various biochemical and physiological processes have been the focus of numerous studies. Its modulation of the activity of various neurotransmitter receptors, such as serotonin, norepinephrine, and dopamine, has been established. 4-Hydroxy Duloxetine has also demonstrated a regulatory effect on the expression of genes that control mood, anxiety, and pain. Furthermore, it has been observed to inhibit the activity of enzymes involved in the metabolism of neurotransmitters, thereby leading to a possible increase in their concentration in the brain.
4-Hydroxy Duloxetine (CAS 662149-13-5) References
- Duloxetine, 60 mg once daily, for major depressive disorder: a randomized double-blind placebo-controlled trial. | Detke, MJ., et al. 2002. J Clin Psychiatry. 63: 308-15. PMID: 12000204
- Metabolism, excretion, and pharmacokinetics of duloxetine in healthy human subjects. | Lantz, RJ., et al. 2003. Drug Metab Dispos. 31: 1142-50. PMID: 12920170
- Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake. | Bymaster, FP., et al. 2003. Bioorg Med Chem Lett. 13: 4477-80. PMID: 14643350
- Exploratory translational modeling approach in drug development to predict human brain pharmacokinetics and pharmacologically relevant clinical doses. | Kielbasa, W. and Stratford, RE. 2012. Drug Metab Dispos. 40: 877-83. PMID: 22287668
- Serotonin and noradrenaline reuptake inhibitors improve micturition control in mice. | Redaelli, M., et al. 2015. PLoS One. 10: e0121883. PMID: 25812116
- Inhibition of Cytochrome P450 by Propolis in Human Liver Microsomes. | Ryu, CS., et al. 2016. Toxicol Res. 32: 207-13. PMID: 27437087
- A rapid LC-MS/MS method for simultaneous determination of quetiapine and duloxetine in rat plasma and its application to pharmacokinetic interaction study. | Chen, X., et al. 2019. J Food Drug Anal. 27: 323-331. PMID: 30648587
- Application of an Inter-Species Extrapolation Method for the Prediction of Drug Interactions between Propolis and Duloxetine in Humans. | Ngo, TL., et al. 2020. Int J Mol Sci. 21: PMID: 32182820
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Hydroxy Duloxetine, 1 mg | sc-210049 | 1 mg | $440.00 |