4-Hydroxy Clonidine (CAS 57101-48-1)

4-Hydroxy Clonidine, also known as 4-OHClon, is a selective α2-adrenoceptor agonist and a metabolite of clonidine. It has gained significant attention in scientific research due to its usefulness in studying the role of α2-adrenoceptors in various physiological and pathological processes. Compared to clonidine, 4-Hydroxy clonidine exhibits higher selectivity and potency for α2-adrenoceptors. This characteristic makes it useful in investigating the specific functions of α2-adrenoceptors. Researchers have utilized 4-Hydroxy Clonidine in multiple research applications, focusing on pain modulation, cardiovascular function, and neuronal signaling mediated by α2-adrenoceptors. Additionally, it has been employed to explore the effects of α2-adrenoceptor agonists on the release of neurotransmitters like norepinephrine and dopamine. The mechanism of action of 4-Hydroxy clonidine involves its role as an agonist for α2-adrenoceptors. These receptors are G-protein-coupled receptors located on the presynaptic membrane of neurons. Upon activation, α2-adrenoceptors inhibit the release of neurotransmitters such as norepinephrine and dopamine. Consequently, sympathetic activity decreases, resulting in various physiological responses.