Molecular structure of 4-(Fluorosulfonyl)benzoic acid, CAS Number: 455-26-5
4-(Fluorosulfonyl)benzoic acid (CAS 455-26-5)
Application:
4-(Fluorosulfonyl)benzoic acid is a xenobiotic substrate analogue
CAS Number:
455-26-5
Purity:
≥94%
Molecular Weight:
204.18
Molecular Formula:
C7H5FO4S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-(Fluorosulfonyl)benzoic acid is a derivative of benzoic acid, with a fluorosulfonyl group attached to the fourth position of the benzene ring. In biochemistry, 4-(Fluorosulfonyl)benzoic acid is used for modifying and labeling proteins, as well as for studying protein-protein interactions. Its unique chemical structure allows it to selectively target specific amino acid residues in proteins, making it useful for investigating the function and regulation of various biological processes.
4-(Fluorosulfonyl)benzoic acid (CAS 455-26-5) References
- Affinity labeling of pig lung glutathione S-transferase pi by 4-(fluorosulfonyl)benzoic acid. | Pettigrew, NE., et al. 1999. Arch Biochem Biophys. 364: 107-14. PMID: 10087171
- Anti-sulfonylbenzoate antibodies as a tool for the detection of nucleotide-binding proteins for functional proteomics. | Moore, LL., et al. 2004. J Proteome Res. 3: 1184-90. PMID: 15595727
- Sulfonyl fluorides as privileged warheads in chemical biology. | Narayanan, A. and Jones, LH. 2015. Chem Sci. 6: 2650-2659. PMID: 28706662
- Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry. | Yang, B., et al. 2018. Proc Natl Acad Sci U S A. 115: 11162-11167. PMID: 30322930
- Development of Covalent Ligands for G Protein-Coupled Receptors: A Case for the Human Adenosine A3 Receptor. | Yang, X., et al. 2019. J Med Chem. 62: 3539-3552. PMID: 30869893
- Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72. | Pettinger, J., et al. 2019. J Med Chem. 62: 11383-11398. PMID: 31725295
- Design and pharmacological profile of a novel covalent partial agonist for the adenosine A1 receptor. | Yang, X., et al. 2020. Biochem Pharmacol. 180: 114144. PMID: 32653590
- Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2. | Ortiz Zacarías, NV., et al. 2021. J Med Chem. 64: 2608-2621. PMID: 33600174
- Irreversible Antagonists for the Adenosine A2B Receptor. | Temirak, A., et al. 2022. Molecules. 27: PMID: 35744918
- Development of subtype-selective covalent ligands for the adenosine A2B receptor by tuning the reactive group. | Beerkens, BLH., et al. 2022. RSC Med Chem. 13: 850-856. PMID: 35923720
- Affinity labeling of glutathione S-transferase, isozyme 4-4, by 4-(fluorosulfonyl)benzoic acid reveals Tyr115 to be an important determinant of xenobiotic substrate specificity. | Barycki, JJ. and Colman, RF. 1993. Biochemistry. 32: 13002-11. PMID: 8241154
- Tyrosine 8 contributes to catalysis but is not required for activity of rat liver glutathione S-transferase, 1-1. | Wang, J., et al. 1996. Protein Sci. 5: 1032-42. PMID: 8762135
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-(Fluorosulfonyl)benzoic acid, 5 g | sc-232277 | 5 g | $275.00 |