Date published: 2026-5-6

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4-Fluorobenzaldehyde (CAS 459-57-4)

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CAS Number:
459-57-4
Purity:
98%
Molecular Weight:
124.11
Molecular Formula:
C7H5FO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Fluorobenzaldehyde stands as a remarkably versatile organic compound, finding utility across a spectrum of scientific and industrial applications. This compound manifests as a colorless and volatile liquid, exuding a potent aroma. It emerges as a derivative of benzaldehyde, an aromatic aldehyde found naturally in various plants. Its broad application spans realms such as organic synthesis and biochemistry, while also contributing to the creation of dyes, fragrances, and pesticides. Within the realm of scientific exploration, 4-Fluorobenzaldehyde boasts a diverse array of functions. It assumes a pivotal role in crafting an array of substances, including dyes, fragrances, and pesticides. Furthermore, its involvement extends to the synthesis of fluorinated aromatic compounds, pivotal in pioneering novel agrochemicals. Additionally, the compound takes part in generating assorted fluorinated heterocyclic compounds, holding promise in the sphere of medicinal chemistry. The underlying mechanism through which 4-Fluorobenzaldehyde operates hinges upon its ability to engage in nucleophilic aromatic substitution reactions. This intricate process orchestrates the substitution of a hydrogen atom on the benzene ring with a fluorine atom. The progression of this reaction navigates through multiple intermediates, encompassing electrophilic and nucleophilic entities, culminating in a transition state. The catalysis of this reaction relies on potent bases like sodium hydroxide.


4-Fluorobenzaldehyde (CAS 459-57-4) References

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  4. Antibacterial Co(II), Ni(II), Cu(II) and Zn(II) complexes of Schiff bases derived from fluorobenzaldehyde and triazoles.  |  Singh, K., et al. 2006. J Enzyme Inhib Med Chem. 21: 557-62. PMID: 17194027
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  7. Experimental, anticancer activity and density functional theory study on the vibrational spectra of 2-(4-fluorobenzylideneamino) propanoic acid.  |  Ruan, M., et al. 2009. Spectrochim Acta A Mol Biomol Spectrosc. 72: 26-31. PMID: 19010721
  8. Synthesis of chalcone (3-(4-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one): advantage of sonochemical method over conventional method.  |  Jarag, KJ., et al. 2011. Ultrason Sonochem. 18: 617-23. PMID: 20980185
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Fluorobenzaldehyde, 10 g

sc-238846
10 g
$31.00

4-Fluorobenzaldehyde, 50 g

sc-238846A
50 g
$77.00