Date published: 2025-9-18

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4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one (CAS 15646-46-5)

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Alternate Names:
(4E)-4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one; Oxazolone
Application:
CAS Number:
15646-46-5
Purity:
≥98%
Molecular Weight:
217.22
Molecular Formula:
C12H11NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Ethoxymethylene-2-phenyl-2-oxazoline-5-one has garnered significant attention in scientific research due to its wide-ranging potential applications. Its versatility is evident as it serves as a chemical reagent in organic synthesis, a catalyst in chemical reactions, and a ligand in coordination chemistry. This compound is believed to act as a ligand, binding to specific proteins and subsequently modulating the activation or inhibition of distinct biochemical pathways. Furthermore, it is postulated to engage with particular enzymes, consequently influencing the activation or inhibition of these vital biochemical pathways.


4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one (CAS 15646-46-5) References

  1. 2-deoxy-d-glucose Ameliorates Animal Models of Dermatitis.  |  Choi, SY., et al. 2020. Biomedicines. 8: PMID: 31991554
  2. Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis.  |  Heo, MJ., et al. 2020. Int J Mol Sci. 21: PMID: 32375285
  3. Mutations in 3β-hydroxysteroid-δ8, δ7-isomerase paradoxically benefit epidermal permeability barrier homeostasis in mice.  |  Dang, E., et al. 2021. Exp Dermatol. 30: 384-389. PMID: 33205489
  4. Delayed Gut Colonization Shapes Future Allergic Responses in a Murine Model of Atopic Dermatitis.  |  Arildsen, AW., et al. 2021. Front Immunol. 12: 650621. PMID: 33815411
  5. Oxazolone-induced gastrointestinal disorders enhance the oral transmission of AA amyloidosis in mice.  |  Kobayashi, H., et al. 2021. J Vet Med Sci. 83: 935-939. PMID: 33883362
  6. Early Stress-Response Gene REDD1 Controls Oxazolone-Induced Allergic Contact Dermatitis.  |  Mirzoeva, S., et al. 2021. J Immunol. 207: 1747-1754. PMID: 34452931
  7. Melatonin Mitigates Oxazolone-Induced Colitis in Microbiota-Dependent Manner.  |  Zhao, ZX., et al. 2021. Front Immunol. 12: 783806. PMID: 35116024
  8. Cynanchi atrati and Its Phenolic Constituent Sinapic Acid Target Regulator of Calcineurin 1 (RCAN1) to Control Skin Inflammation.  |  Kim, SS., et al. 2022. Antioxidants (Basel). 11: PMID: 35204088
  9. Modulating gut dysbiosis and mitochondrial dysfunction in oxazolone-induced ulcerative colitis: the restorative effects of β-glucan and/or celastrol.  |  Safwat El-Deeb, O., et al. 2022. Redox Rep. 27: 60-69. PMID: 35246012
  10. Glucocorticoid induced group 2 innate lymphoid cell overactivation exacerbates experimental colitis.  |  Feng, B., et al. 2022. Front Immunol. 13: 863034. PMID: 36032134
  11. Effects of Oral Administration of Lactiplantibacillus Plantarum APsulloc 331261 (GTB1TM) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models.  |  Kim, SY., et al. 2022. Evid Based Complement Alternat Med. 2022: 4520433. PMID: 36110182
  12. Cynanoside F Controls Skin Inflammation by Suppressing Mitogen-Activated Protein Kinase Activation.  |  Fleitas, MMD., et al. 2022. Antioxidants (Basel). 11: PMID: 36139814
  13. Observation of hapten-induced sensitization responses for the development of a mouse skin sensitization test, including the elicitation phase.  |  Kamata, R., et al. 2022. Sci Rep. 12: 19898. PMID: 36400912
  14. Moderating Gut Microbiome/Mitochondrial Axis in Oxazolone Induced Ulcerative Colitis: The Evolving Role of β-Glucan and/or, Aldose Reductase Inhibitor, Fidarestat.  |  El-Deeb, OS., et al. 2023. Int J Mol Sci. 24: PMID: 36769034

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one, 1 g

sc-252152
1 g
$85.00

4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one, 5 g

sc-252152A
5 g
$300.00