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4-Epitetracycline hydrochloride (CAS 23313-80-6)

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Alternate Names:
Quatrimycin hydrochloride
Application:
4-Epitetracycline hydrochloride is an antibiotic and cell selection agent
CAS Number:
23313-80-6
Molecular Weight:
480.90
Molecular Formula:
C22H24N2O8•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Epitetracycline hydrochloride operates through a mechanism of action akin to other tetracycline antibiotics. Its functionality involves hindering the growth and reproduction of bacteria by attaching to the bacteria′s 30S ribosomal subunit. By doing so, it obstructs the binding of aminoacyl tRNA to the A site of the ribosome, impeding protein synthesis within the bacteria. Consequently, this interruption culminates in the demise of the bacteria.


4-Epitetracycline hydrochloride (CAS 23313-80-6) References

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  2. Occurrence and loss over three years of 72 pharmaceuticals and personal care products from biosolids-soil mixtures in outdoor mesocosms.  |  Walters, E., et al. 2010. Water Res. 44: 6011-20. PMID: 20728197
  3. Tetracycline speciation during molecular imprinting in xerogels results in class-selective binding.  |  Mojica, ER., et al. 2011. Analyst. 136: 749-55. PMID: 21132193
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  5. A novel green chemistry method for nonaqueous extraction and high-performance liquid chromatography detection of first-, second-, and third-generation tetracyclines, 4-epitetracycline, and tylosin in animal feeds.  |  Granados-Chinchilla, F., et al. 2012. J Agric Food Chem. 60: 7121-8. PMID: 22738432
  6. Tetracycline and 4-epitetracycline modified the in vitro catabolic activity and structure of a sediment microbial community from a tropical tilapia farm idiosyncratically.  |  Granados-Chinchilla, F., et al. 2013. J Environ Sci Health B. 48: 291-301. PMID: 23374048
  7. pH-dependent spectroscopy of tetracycline and its analogs.  |  Mojica, ER., et al. 2014. J Fluoresc. 24: 1183-98. PMID: 24806484
  8. Bioconcentration, metabolism and the effects of tetracycline on multiple biomarkers in Chironomus riparius larvae.  |  Xie, Z., et al. 2019. Sci Total Environ. 649: 1590-1598. PMID: 30308927
  9. Ultrasensitive high-performance liquid chromatography determination of tetracycline antibiotics and their 4-epimer derivatives based on dual effect of methanesulfonic acid.  |  Lai, X., et al. 2020. J Sep Sci. 43: 398-405. PMID: 31637854
  10. Toxicity of tetracycline and its transformation products to a phosphorus removing Shewanella strain.  |  Long, S., et al. 2020. Chemosphere. 246: 125681. PMID: 31896014
  11. Effects of different oxygen conditions on pollutants removal and the abundances of tetracycline resistance genes in activated sludge systems.  |  Fan, Z., et al. 2022. Chemosphere. 291: 132681. PMID: 34718015
  12. Diastereomer recognition of three pairs of tetracyclines by electrospray ionization mass spectrometry.  |  Zhu, P., et al. 2022. Rapid Commun Mass Spectrom. 36: e9221. PMID: 34761454
  13. Tetracyclines in pasteurized milk commercialized in São Paulo, Brazil: occurrence and dietary risk assessment based on single and combined exposure with polyether ionophores.  |  Spisso, BF., et al. 2022. Food Addit Contam Part B Surveill. 15: 254-265. PMID: 35861122
  14. Simultaneous separation and quantitative determination of tetracycline, anhydrotetracycline, 4-epitetracycline, and 4-epi-anhydrotetracycline in degraded tetracyclines by thin-layer chromatography.  |  Alvarez Fernandez, A., et al. 1969. J Pharm Sci. 58: 443-6. PMID: 5797561
  15. Separation and quantitation of chlortetracycline, 4-epitetracycline, 4-epianhydrotetracycline, and anhydrotetracycline in tetracycline by high-performance liquid chromatography.  |  Muhammad, N. and Bodnar, JA. 1980. J Pharm Sci. 69: 928-30. PMID: 7400938

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Epitetracycline hydrochloride, 100 mg

sc-232640
100 mg
$317.00