Date published: 2025-9-14

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4-Epi Minocycline (CAS 43168-51-0)

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Alternate Names:
Epiminocycline
Application:
4-Epi Minocycline is an impurity of minocycline
CAS Number:
43168-51-0
Molecular Weight:
457.48
Molecular Formula:
C23H27N3O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Epi Minocycline is a tetracycline and is the 4-epimer of minocycline. In research applications, it is utilized to study the structure-activity relationships of tetracycline compounds. Its utilization in research helps in understanding the biochemical kinetics and mechanisms of minocycline and its related compounds. 4-Epi Minocycline is often used as a reference compound for analytical methods aimed at quantifying minocycline and its metabolites in biological samples. Additionally, it serves in comparative studies to assess the differences in biological activity between it and its parent compound, minocycline. Research involving 4-Epi Minocycline is also significant in the synthesis of new tetracycline derivatives and the exploration of their potential biological effects.


4-Epi Minocycline (CAS 43168-51-0) References

  1. Liquid chromatography for the quantitative analysis of antibiotics--some applications using poly(styrene-divinylbenzene).  |  Hoogmartens, J. 1992. J Pharm Biomed Anal. 10: 845-50. PMID: 1298392
  2. Validated stability-indicating densitometric thin-layer chromatography: application to stress degradation studies of minocycline.  |  Jain, N., et al. 2007. Anal Chim Acta. 599: 302-9. PMID: 17870294
  3. Diagnostic criteria for autoimmune hepatitis: what is the gold standard?  |  Kochar, R. and Fallon, M. 2010. Hepatology. 51: 350-1; author reply 351. PMID: 20034043
  4. Analysis of a second-generation tetracycline antibiotic minocycline in human plasma by LC-MS/MS.  |  Patel, DS., et al. 2011. Bioanalysis. 3: 2177-94. PMID: 21985413
  5. Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa.  |  Chen, Q., et al. 2019. Mol Pharm. 16: 1606-1619. PMID: 30817887
  6. Topical minocycline formulations: Evaluation and comparison of dermal uptake efficacy.  |  Lac, D., et al. 2019. Int J Pharm X. 1: 100009. PMID: 31517274
  7. Novel Therapeutic Strategies Applied to Pseudomonas aeruginosa Infections in Cystic Fibrosis.  |  Chirgwin, ME., et al. 2019. Materials (Basel). 12: PMID: 31817881
  8. Separation and detection of tetracyclines by high-speed liquid chromatography.  |  Butterfield, AG., et al. 1973. Antimicrob Agents Chemother. 4: 11-5. PMID: 4791479
  9. Metabolism and tissue distribution of radioisotopically labelled minocycline.  |  Kelly, RG. and Kanegis, LA. 1967. Toxicol Appl Pharmacol. 11: 171-83. PMID: 6056150
  10. Assay and purity control of minocycline by thin-layer chromatography using UV and fluorescence densitometry--a comparison with liquid chromatography.  |  Naidong, W., et al. 1995. J Pharm Biomed Anal. 13: 905-10. PMID: 8562615
  11. Capillary zone electrophoresis of minocycline.  |  Li, YM., et al. 1996. J Pharm Biomed Anal. 14: 1095-9. PMID: 8818020
  12. In situ degradation: a new concept for system suitability tests in monographs of the European Pharmacopoeia.  |  Rose, U. 1998. J Pharm Biomed Anal. 18: 1-14. PMID: 9863938

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Epi Minocycline, 0.5 mg

sc-210033A
0.5 mg
$500.00

4-Epi Minocycline, 1 mg

sc-210033
1 mg
$918.00

4-Epi Minocycline, 5 mg

sc-210033B
5 mg
$3927.00

4-Epi Minocycline, 10 mg

sc-210033C
10 mg
$5518.00

Can you tell the me the approximate purity of the Epiminocycline? Best we can fine currently is ≥ 85%

Asked by: Balderash
Due to lot to lot variation, please contact Technical Service for purity.
Answered by: Tech Sales
Date published: 2021-06-09

Are the Mass Spec and/or H-NMR available for the most recent lot? Have already received the CoA.

Asked by: Jz28sail
Thank you for your question. Yes, we are happy to provide the Mass Spec and/or H-NMR data for sc-210033, 4-Epi Minocycline if it is available. For many of SCBT's Chemical products, we are able to provide additional data upon request. Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Chemical Support 5
Date published: 2017-04-14
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Rated 5 out of 5 by from Used to verify impurities.The product is exactly what was described and worked as intended with our method.
Date published: 2016-11-21
Rated 5 out of 5 by from NaidongNaidong, W. et al. (PubMed 8562615) used thin-layer chromatography and fluorescence densitometry to assay and determine impurities of minocycline, such as 4-Epi Minocycline. -SCBT Publication Review
Date published: 2015-06-27
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4-Epi Minocycline | CAS 43168-51-0 is rated 5.0 out of 5 by 2.
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