Date published: 2025-9-26

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4-(Dimethylamino)phenyl isocyanate (CAS 16315-59-6)

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CAS Number:
16315-59-6
Molecular Weight:
162.19
Molecular Formula:
C9H10N2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-(Dimethylamino)phenyl isocyanate is a colorless solid with various applications in scientific research. It dissolves readily in organic solvents and plays a role in synthesizing a wide range of compounds. This compound serves as a catalyst in the production of polyurethanes, polyamides, and other polymers, contributing to their formation. Its distinctive structure and properties make it an indispensable resource in the field of synthetic organic chemistry.


4-(Dimethylamino)phenyl isocyanate (CAS 16315-59-6) References

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  2. Experimental and Theoretical Evidence for a Concerted Catalysis by Water Clusters in the Hydrolysis of Isocyanates.  |  Raspoet, G., et al. 1998. J Org Chem. 63: 6867-6877. PMID: 11672307
  3. Positive dendritic effects on the electron-donating potencies of poly(propylene imine) dendrimers.  |  Ong, W. and McCarley, RL. 2005. Org Lett. 7: 1287-90. PMID: 15787488
  4. Synthesis of spirohydantoins and spiro-2,5-diketopiperazines via resin-bound cyclic alpha,alpha-disubstituted alpha-amino esters.  |  Kuster, GJ., et al. 2006. J Comb Chem. 8: 85-94. PMID: 16398558
  5. Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.  |  Gieling, RG., et al. 2012. J Med Chem. 55: 5591-600. PMID: 22621623
  6. Development of a novel method for quantification of sterols and oxysterols by UPLC-ESI-HRMS: application to a neuroinflammation rat model.  |  Ayciriex, S., et al. 2012. Anal Bioanal Chem. 404: 3049-59. PMID: 23010846
  7. PREPARATION AND EVALUATION OF HPLC CHIRAL STATIONARY PHASES BASED ON CATIONIC/BASIC DERIVATIVES OF CYCLOFRUCTAN 6.  |  Padivitage, NL., et al. 2015. J Liq Chromatogr Relat Technol. 38: 550-560. PMID: 25663797
  8. P2X7-pannexin-1 and amyloid β-induced oxysterol input in human retinal cell: Role in age-related macular degeneration?  |  Olivier, E., et al. 2016. Biochimie. 127: 70-8. PMID: 27109381
  9. Lipid deregulation in UV irradiated skin cells: Role of 25-hydroxycholesterol in keratinocyte differentiation during photoaging.  |  Olivier, E., et al. 2017. J Steroid Biochem Mol Biol. 169: 189-197. PMID: 27208628
  10. Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer.  |  Kimbung, S., et al. 2017. Endocr Relat Cancer. 24: 339-349. PMID: 28442559
  11. 25-Hydroxycholesterol induces both P2X7-dependent pyroptosis and caspase-dependent apoptosis in human skin model: New insights into degenerative pathways.  |  Olivier, E., et al. 2017. Chem Phys Lipids. 207: 171-178. PMID: 28599978
  12. The kinetics of hydrolysis of methyl and phenyl lsocyanates. Journal of the Chemical Society  |  Castro, E. A., Moodie, R. B., & Sansom, P. J. 1985. Perkin Transactions 2. (5): 737-742.
  13. Development of a highly sensitive analytical technique for surfactants by time-of-flight secondary ion mass spectrometry  |  Tanji, N., & Okamoto, M. 2006. Applied surface science. 252(19): 6664-6667.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-(Dimethylamino)phenyl isocyanate, 1 g

sc-226409
1 g
$316.00