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![4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide (CAS 193551-00-7) - chemical structure image](https://media.scbt.com/product/4-dimethylamino-n-6-hydroxyamino-6-oxohexyl-benzamide-193551-00-7-structure_08_27_t_82787.jpg "Molecular structure of 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide, CAS Number: 193551-00-7")
Molecular structure of 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide, CAS Number: 193551-00-7
4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide (CAS 193551-00-7)
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Alternate Names:
4-(dimethylamino)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide
Application:
4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide is a selective HDAC1 inhibitor
CAS Number:
193551-00-7
Purity:
>98%
Molecular Weight:
293.37
Molecular Formula:
C15H23N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide is a selective HDAC1 (histone deacetylase) inhibitor. It is very similar in structure to M 344 (sc-203124), and has similar potency to trapoxin A (sc-253730) and trapoxin B. Trichostatin A (sc-3511) is a more potent inhibitor of the HDAC enzyme, however this 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide compound has equivalent selectivity and is much more cost-effective for the inhibition of HDAC. The deacetylation of histones by HDAC is associated with transcriptional silencing.
4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide (CAS 193551-00-7) References
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- Histone deacetylases and ASYMMETRIC LEAVES2 are involved in the establishment of polarity in leaves of Arabidopsis. | Ueno, Y., et al. 2007. Plant Cell. 19: 445-57. PMID: 17293570
- Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells. | Huber, K., et al. 2011. J Biol Chem. 286: 22211-8. PMID: 21531716
- Dissecting histone deacetylase role in pulmonary arterial smooth muscle cell proliferation and migration. | Galletti, M., et al. 2014. Biochem Pharmacol. 91: 181-90. PMID: 25063234
- Resveratrol regulates PTEN/Akt pathway through inhibition of MTA1/HDAC unit of the NuRD complex in prostate cancer. | Dhar, S., et al. 2015. Biochim Biophys Acta. 1853: 265-75. PMID: 25447541
- Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting. | Bazou, D., et al. 2016. Sci Rep. 6: 34046. PMID: 27669993
- Role of histone deacetylase 1 in distant metastasis of pancreatic ductal cancer. | Shinke, G., et al. 2018. Cancer Sci. 109: 2520-2531. PMID: 29917299
- Valproic acid promotes the neuronal differentiation of spiral ganglion neural stem cells with robust axonal growth. | Moon, BS., et al. 2018. Biochem Biophys Res Commun. 503: 2728-2735. PMID: 30119886
- Developmental Programming of Thermonastic Leaf Movement. | Park, YJ., et al. 2019. Plant Physiol. 180: 1185-1197. PMID: 30948554
- miR-449a Repression Leads to Enhanced NOTCH Signaling in TMPRSS2:ERG Fusion Positive Prostate Cancer Cells. | Bauer, S., et al. 2021. Cancers (Basel). 13: PMID: 33669024
- Arabidopsis ASYMMETRIC LEAVES2 (AS2): roles in plant morphogenesis, cell division, and pathogenesis. | Machida, Y., et al. 2022. J Plant Res. 135: 3-14. PMID: 34668105
- Histone deacetylase-2 controls IL-1β production through the regulation of NLRP3 expression and activation in tuberculosis infection. | Moreira, JD., et al. 2022. iScience. 25: 104799. PMID: 35982796
- A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. | Taunton, J., et al. 1996. Science. 272: 408-11. PMID: 8602529
Inhibitor of:
HDAC, and HDAC1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide, 1 mg | sc-223859 | 1 mg | $39.00 | |||
4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide, 5 mg | sc-223859A | 5 mg | $155.00 | |||
4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide, 10 mg | sc-223859B | 10 mg | $272.00 | |||
4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide, 25 mg | sc-223859C | 25 mg | $588.00 | |||
4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide, 60 mg | sc-223859D | 60 mg | $1254.00 |