4-Desmethyl Istradefylline (CAS 160434-48-0)

4-Desmethyl Istradefylline, also referred to as 4-Desmethyl Theophylline, 4-Desmethyl Theobromine, and 4-Desmethyl Theobromide, is a naturally occurring derivative of methylxanthine. It can be found in the leaves of the tea plant (Camellia sinensis) and the cocoa bean (Theobroma cacao). This compound serves as a stimulant for the central nervous system.Studies have shown that 4-Desmethyl Istradefylline possesses neuroprotective properties against oxidative stress in animal models of Parkinson′s disease, Alzheimer′s disease, and Huntington′s disease. Additionally, it has been observed to lower blood pressure and enhance cardiac function in animal models of hypertension.Research has been conducted to evaluate its potential to reduce blood glucose levels in animal models of diabetes.The central nervous system is affected by 4-Desmethyl Istradefylline through its ability to block adenosine receptors, which play a role in the regulation of sleep, wakefulness, and cardiac function. It also acts as an antagonist of the adenosine A2A receptor, which is involved in regulating dopamine release in the brain. By inhibiting these receptors, 4-Desmethyl Istradefylline is believed to exert its neuroprotective, antihypertensive, and antidiabetic effects.