4-Deoxy-L-fucose (CAS 61244-62-0)

4-Deoxy-L-fucose, a derivative of L-fucose, plays a crucial role in scientific research, particularly in the fields of glycobiology and carbohydrate chemistry. This compound has been extensively studied for its involvement in various biological processes, including cell adhesion, migration, and immune response modulation. Mechanistically, 4-deoxy-L-fucose acts as a competitive inhibitor of fucose-utilizing enzymes, thereby influencing glycosylation patterns and cellular signaling pathways. Research has demonstrated its utility as a tool for probing the specificity and kinetics of fucosyltransferases and fucose-binding lectins, shedding light on the molecular mechanisms underlying fucose-mediated interactions in biological systems. Furthermore, 4-deoxy-L-fucose has been employed in studies investigating the role of fucose-containing glycans in host-pathogen interactions, providing insights into the molecular basis of microbial adhesion and invasion. Additionally, this compound has been utilized as a substrate analogue for the synthesis of fucose-modified oligosaccharides and glycoconjugates, facilitating the development of novel glycan-based research tools and diagnostic probes. Its structural similarity to L-fucose also renders it suitable for structural and functional studies of fucose-binding proteins and carbohydrate-binding domains. Overall, 4-deoxy-L-fucose serves as a valuable tool for advancing our understanding of fucose biology and its implications in health and disease.