Date published: 2026-5-31

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4-Cyanophenyl isocyanate (CAS 40465-45-0)

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Application:
4-Cyanophenyl isocyanate is a specialty product for proteomics research
CAS Number:
40465-45-0
Molecular Weight:
144.13
Molecular Formula:
C8H4N2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Cyanophenyl isocyanate is a highly versatile compound with broad applications in the chemical, and biological sciences. 4-Cyanophenyl isocyanate finds utility in the study of enzyme-catalyzed reactions, as well as in the exploration of biochemical and physiological processes. The scientific research community has employed 4-Cyanophenyl isocyanate in diverse research applications. It has proven instrumental in investigating enzyme-catalyzed reactions, shedding light on key mechanisms underlying biochemical and physiological processes. Furthermore, the compound has demonstrated its significance in material science by contributing to the development of novel polymers and nanomaterials. Mechanistically, 4-Cyanophenyl isocyanate acts as an isocyanate, readily reacting with amines, alcohols, and thiols to yield amides, esters, and thioesters, respectively. It can also react with water to form a carbamate, which can subsequently undergo hydrolysis to generate an amide. Notably, 4-Cyanophenyl isocyanate exhibits self-reactivity, enabling the formation of a cyclic urea through intramolecular reactions.


4-Cyanophenyl isocyanate (CAS 40465-45-0) References

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  3. Development of a concise, asymmetric synthesis of a smoothened receptor (SMO) inhibitor: enzymatic transamination of a 4-piperidinone with dynamic kinetic resolution.  |  Peng, Z., et al. 2014. Org Lett. 16: 860-3. PMID: 24502520
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  6. Synthesis and Leishmanicidal Activity of Novel Urea, Thiourea, and Selenourea Derivatives of Diselenides.  |  Díaz, M., et al. 2019. Antimicrob Agents Chemother. 63: PMID: 30782984
  7. 2,2-Dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants.  |  Pirotte, B., et al. 2019. Medchemcomm. 10: 431-438. PMID: 31015906
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  10. Design, Synthesis and Biological Evaluation of Phenyl Urea Derivatives as IDO1 Inhibitors.  |  Zhou, C., et al. 2020. Molecules. 25: PMID: 32210078
  11. TCT-mediated click chemistry for the synthesis of nitrogen-containing functionalities: conversion of carboxylic acids to carbamides, carbamates, carbamothioates, amides and amines.  |  Ahmed, R., et al. 2022. Org Biomol Chem. 20: 4942-4948. PMID: 35660834
  12. Hydroboration of isocyanates: cobalt-catalyzed vs. catalyst-free approaches.  |  Gudun, KA., et al. 2022. Org Biomol Chem. 20: 6821-6830. PMID: 35968649
  13. Selective hydroboration of electron-rich isocyanates by an NHC-copper(I) alkoxide.  |  English, LE., et al. 2023. Chem Commun (Camb). 59: 1074-1077. PMID: 36621804

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Cyanophenyl isocyanate, 2 g

sc-232625
2 g
$128.00